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IMPACTT Newsletter | June/July 2023
Dear ,
Welcome to our joint June/July 2023 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS

Having IMPACTT Symposium

Thank you to our speakers, sponsors, and attendees of our sold-out Having IMPACTT 3 Symposium last month on July 10-12, 2023 in Canmore, AB! If you missed us this year, don’t worry - details about next year’s symposium are coming soon.
Congratulations to our award recipients, and to everyone who presented their research!
Best Short Talk: Aviva Rotter-Maskowitz, Weizmann Institute of Science
Best Flash Talk: Gillian Tanabe, University of Ottawa
1st Place Poster: Leah D’Aloisio, University of British Columbia Okanagan
2nd Place Poster: Peter Dobranowski, University of Ottawa
3rd Place Poster: Dr. Saif Sikdar, University of Calgary
Postdoctoral Travel Award: Dr. Han Fang, McMaster University
Graduate Travel Award: Sara Shama, University of Toronto

CBW-IMPACTT Microbiome Analysis Workshop

Our joint CBW-IMPACTT Microbiome Analysis Workshop took place on July 5-7, 2023 at the University of Calgary. We are grateful to the hard work of our instructors and TAs and the enthusiasm of our attendees for making this sold-out workshop a success! Check out the Canadian Bioinformatics Workshops website for lots more upcoming workshops across Canada.

IMPACTT TEAM & NETWORK NEWS
Dr. Marie-Claire Arrieta (Platform 2 Co-Lead) received a UCalgary Research Excellence Chair, a prestigious new program that recognizes research leaders at the University of Calgary. Congratulations!
Dr. Laura Sycuro’s (Platform 4 Lead) MSc student Josh Potyondi successfully defended his thesis on “Defining the relationships between Gardnerella biofilm composition, antimicrobial resistance and recurrent vaginal dysbiosis.” Congratulations!
Dr. Marie-Claire Arrieta’s (Platform 2 Co-Lead) Postdoctoral Fellow Dr. Michelle Asbury received a L’Oréal Canada For Women in Science Research Excellence Fellowship. This is a prestigious fellowship with only 5 annual endowments. Congratulations!

IN THE MEDIA
Dr. Laura Sycuro (Platform 4 Lead) was interviewed for Episode 148 of the EMJ Podcast on “The Mysteries of the Maternal Microbiome”. Listen to the full episode here.

NEW PUBLICATIONS

New Publications in the Microbiome World

Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives
Raygoza Garay et al (including Platform 3 Lead Dr. Karen Madsen and CMI2 Team Grant Leads Dr. Anne Griffiths, Dr. David Mack, Dr. Michael Surette, & Dr. Bruce Vallance). Gastroenterology. 30 May 2023.
Highlights: In this prospective cohort study, researchers enrolled 3,483 healthy first-degree relatives (FDRs) of patients with Crohn’s disease (CD), and monitored them for a median of 5.4 years, to test if their gut microbiome composition could be used to predict the risk of developing CD. In this cohort, 73 individuals developed CD during the study. They used a validation cohort to develop a microbiome risk score (MRS) model, which was able to identify individuals that developed CD up to 5 years before disease onset. This is the first study to show that gut microbiome composition is associated with future onset of CD.
Birth Mode Does Not Determine the Presence of Shared Bacterial Strains between the Maternal Vaginal Microbiome and the Infant Stool Microbiome
Dos Santos et al. (including IMPACTT Co-Applicant Dr. Janet Hill). Microbiology Spectrum. 20 Jun 2023.
Highlights: Previous studies have found links between delivery mode (vaginal vs. c-section) and a variety of diseases, such as asthma, type I diabetes, and other chronic and autoimmune diseases. It has been hypothesized that early life gut microbiome dysbiosis may play a role in the development of these diseases, especially since c-section infants are not immediately exposed to the maternal vaginal microbiome at delivery. In this study, the researchers set out to determine if the maternal vaginal microbiome is vertically transmitted to infants. They sequenced 585 maternal vaginal microbiomes and 1,027 infant stool microbiomes (collected at multiple time points), and found that 204/585 mother-infant pairs showed at least one potential ASV transfer event. Delivery mode did not affect the distribution of these potential transfer events, nor did antibiotic exposure. Based on these results, the researchers show that vertical transmission of the maternal vaginal microbiota is likely limited and that transmission from other maternal body sites, including the gut and breast milk, may compensate for the lack of maternal vaginal microbiome exposure during c-section delivery.

New Publications from our IMPACTT Team and Network

Dr. Anita Kozyrskyj (Platform 2 Lead) & Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Maternal Iron Status Is Dynamic Throughout Pregnancy and Might Predict Birth Outcomes in a Sex Dependent Manner: Results from the Alberta Pregnancy Outcomes and Nutrition (APrON) Cohort Study
Evanchuk et al. The Journal of Nutrition. 29 Jun 2023.
Dr. David Mack (CMI2 Team Grant Lead) & Dr. Caitlin Simopoulos (IMPACTT Mentee)
Revealing proteome-level functional redundancy in the human gut microbiome using ultra-deep metaproteomics
Li et al. Nature Communications. 10 Jun 2023.
Dr. Meghan Azad (CMI2 Team Grant Lead) 7 Dr. Merilee Brockway (IMPACTT Mentee)
Human Milk Micronutrients and Child Growth and Body Composition in the First 2 y: A Systematic Review
Reyes et al. Advances in Nutrition. 13 Jun 2023.
Dr. Marie-Claire Arrieta (Platform 2 Co-Lead) & Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Exploring associations between the gut microbiota and full-scale intelligence in preschool children
Van de Wouw et al. Neuroscience Letters. 27 Jun 2023.
Dr. Anne Griffiths & Dr. David Mack (CMI2 Team Grant Leads)
Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn disease, and celiac disease
Braun et al. JCI Insight. 01 Jun 2023.
Dr. Wendy Lou, Dr. Padmaja Subbarao, & Dr. Stuart Turvey (CMI2 Team Grant Leads)
Association of COVID-19 Government-Instituted Mask Mandates With Incidence of Mask Use Among Children in Alberta, Canada
Hahn et al. JAMA Network Open. 08 Jun 2023.
Di-(2-Ethylhexyl) Phthalate (DEHP) in House Dust in Canadian Homes: Behaviors and Associations with Housing Characteristics and Consumer Products
Zhang et al. Indoor Air. 25 Jul 2023.
Dr. Padmaja Subbarao, & Dr. Stuart Turvey (CMI2 Team Grant Leads)
Association between gas stove use and childhood asthma in the Canadian CHILD Cohort Study
Bédard et al. Canadian Journal of Public Health. 09 Jun 2023.
Dr. Karen Madsen (Platform 3 Lead) & Dr. Benjamin Willing (IMPACTT Co-Applicant)
The Need for FibEr Addition in SympTomatic Heart Failure (FEAST-HF): A randomized controlled pilot trial
Colin-Ramirez. CJC Open. 17 Jul 2023.
Dr. Adam Burgener & Dr. Vanessa Poliquin (CMI2 Team Grant Leads)
Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
Farr Zuend et al. Microbiome. 25 Jul 2023.
Dr. Philippe Gros (Platform 1 Co-Lead)
Biphosphoglycerate mutase: A novel therapeutic target for malaria?
Azzuolo et al. Transfusion Medicine Reviews. 13 Jul 2023.
Dr. Paul Kubes (Platform 1 Co-Lead)
Intravital imaging of 3 different microvascular beds in SARS-CoV-2-infected mice
Silva et al. Blood Advances. 12 Jun 2023.
Dr. Marie-Claire Arrieta (Platform 2 Co-Lead)
The global human gut microbiome: genes, lifestyles, and diet
Parizadeh & Arrieta. Trends in Molecular Medicine. 27 Jul 2023.
Dr. Karen Madsen (Platform 3 Lead)
Safety and Outcomes of Bariatric Surgery in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Wilson et al. Foregut. 12 Jul 2023.
Dr. Laura Sycuro (Platform 4 Lead)
Low prevalence of bacterial vaginosis in Kenyan adolescent girls, and rapid incidence after first sex
Roxby et al. American Journal of Obstetrics and Gynecology. 28 Jun 2023.
Dr. Celia Greenwood (Platform 5 Lead)
Dose-dependent Association of Alcohol Consumption With Obesity and Type 2 Diabetes: Mendelian Randomization Analyses
Lu et al. The Journal of Clinical Endocrinology & Metabolism. 27 Jun 2023.
Development of risk prediction models for depression combining genetic and early life risk factors
Lu et al. Frontiers in Neuroscience. 18 Jul 2023.
Dr. William Hsiao (Platform 5 Co-Lead)
OntoTrek: 3D visualization of application ontology class hierarchies
Dooley et al. PLOS One. 02 Jun 2023.
Dr. Markus Geuking (Education Lead)
Expanding the role of MHC class II on intestinal epithelial cells
Geuking. Mucosal Immunology. 05 Jun 2023.
Dr. John Conly (IMPACTT Co-Applicant)
Congenital SARS-CoV-2 Infection in Two Neonates with Confirmation by Viral Culture of the Placenta in One Case
Vayalumkal et al. Viruses. 31 May 2023.
Effect of a Continuous Bedside Pressure Mapping System for Reducing Interface Pressures
Ho et al. JAMA Network Open. 02 Jun 2023.
Dr. Irina Dinu (IMPACTT Co-Applicant)
Maternal co-exposure to mercury and perfluoroalkyl acid isomers and their associations with child neurodevelopment in a Canadian birth cohort
Reardon et al. Environment International. 05 Jul 2023.
Dr. Janet Hill (IMPACTT Co-Applicant)
Improving the consistency of experimental swine dysentery inoculation strategies
Parra-Aguirre et al. Veterinary Research. 16 Jun 2023.
Evaluating cpn60 for high-resolution profiling of the mammalian skin microbiome and detection of phylosymbiosis
Umbach et al. ISME Communications. 07 Jul 2023.
Dr. Thomas Louie (IMPACTT Co-Applicant)
Safety of fecal microbiota, live-jslm (REBYOTA™) in individuals with recurrent Clostridioides difficile infection: data from five prospective clinical trials
Lee et al. Therapeutic Advances in Gastroenterology. 12 Jun 2023.
Insights into the Evolving Epidemiology of Clostridioides difficile Infection and Treatment: A Global Perspective
Liu et al. Antibiotics. 1 Jul 2023.
Dr. Jens Walter (IMPACTT Co-Applicant)
Impact of different fibre ingredients on a low-FODMAP biscuit model system
Sahin et al. Food & Function. 09 Jul 2023.
Dr. Benjamin Willing (IMPACTT Co-Applicant)
Antibacterial and enzyme inhibitory activities of flavan-3-ol monomers and procyanidin-rich grape seed fractions
Solis Ares et al. Journal of Functional Foods. 23 Jun 2023.
Comparing the impact of mixed-culture microbial communities and fecal transplant on the intestinal microbiota and metabolome of weaned piglets
Rahman et al. FEMS Microbiology Ecology. 22 Jun 2023.
Dr. Eytan Wine (IMPACTT Co-Applicant)
Use of fiber-containing enteral formula in pediatric clinical practice: an expert opinion review
Lionetti et al. Expert Review of Gastroenterology & Hepatology. 05 Jun 2023.
Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
Delivery mechanism can enhance probiotic activity against honey bee pathogens
Daisley et al. The ISME Journal. 14 Jun 2023.
Reductive metabolism of azo dyes and drugs: Toxicological implications
Josephy & Allen-Vercoe. Food and Chemical Toxicology. 15 Jul 2023.
Holtiella tumoricola gen. nov. sp. nov., isolated from a human clinical sample
Allen-Vercoe et al. International Journal of Systematic and Evolutionary Microbiology. 12 Jul 2023.
A microbial consortium alters intestinal Pseudomonadota and antimicrobial resistance genes in individuals with recurrent Clostridioides difficile infection
Rooney et al. mBio. 05 Jul 2023.
Strain specificity in fusobacterial co-aggregation with colorectal cancer-relevant species
Robinson & Allen-Vercoe. Anaerobe. 20 Jul 2023.
Dr. Robert Bandsma (CMI2 Team Grant Lead)
Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function
Chi et al. Cellular and Molecular Life Sciences. 20 Jun 2023.
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Impact of a community-based intervention package delivered through community health workers on post-partum care practices: a cluster randomized controlled trial
Ariff et al. Journal of Public Health. 07 Jun 2023.
Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021
BDG 2021 Sickle Cell Disease Collaborators. The Lancet Haematology. 15 Jun 2023.
What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight
Koivu et al. The American Journal of Clinical Nutrition. 16 Jun 2023.
A scoping review establishes need for consensus guidance on reporting health equity in observational studies
Wang et al. Journal of Clinical Epidemiology. 15 Jun 2023.
Predictors and disparities in neonatal and under 5 mortality in rural Pakistan: cross sectional analysis
Memon et al. The Lancet Regional Health. 20 Jun 2023.
NAUNEHAL; Integrated immunization and MNCH interventions: A quasi-experimental study–Protocol
Ataullahjan et al. PLOS One. 29 Jun 2023.
Exploring Knowledge and Perceptions of Polio Disease and Its Immunization in Polio High-Risk Areas of Pakistan
Habib et al. Vaccines. 05 Jul 2023.
Dr. Adam Burgener (CMI2 Team Grant Lead)
Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections
Dabee et al. Current HIV/AIDS Reports. 21 Jun 2023.
Adverse childhood experiences and lifelong health
Bhutta et al. Nature Medicine. 18 Jul 2023.
The global challenge of childhood obesity and its consequences: what can be done?
Bhutta et al. The Lancet Global Health. Aug 2023.
Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study
Ohuma et al. The Lancet Haematology. 20 Jul 2023.
A Systematic Review of Persistent Clinical Features After SARS-CoV-2 in the Pediatric Population
Jiang et al. Pediatrics. 21 Jul 2023.
Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Prenatal mental health data and birth outcomes in the pregnancy during the COVID-19 Pandemic dataset
Lebel et al. Data in Brief. 06 Jul 2023.
Risk for Developmental Delay Among Infants Born During the COVID-19 Pandemic
Giesbrecht et al. Journal of Developmental & Behavioral Pediatrics. Aug 2023.
Dr. Anne Griffiths (CMI2 Team Grant Lead)
Difficult-to-treat inflammatory bowel disease: results from an international consensus meeting
Parigi et al. The Lancet Gastroenterology & Hepatology. 06 Jul 2023.
Dr. Steven Kembel (CMI2 Team Grant Lead)
Long-Term Simulated Nitrogen Deposition Has Moderate Impacts on Soil Microbial Communities across Three Bioclimatic Domains of the Eastern Canadian Forest
Renaudin et al. Forests. 30 May 2023.
Drivers of contrasting boreal understory vegetation in coniferous and broadleaf deciduous alternative states
Rodríguez-Rodríguez et al. Ecological Monographs. 12 Jun 2023.
Dr. Caroline Kramer (CMI2 Team Grant Lead)
Baseline determinants of remission of type 2 diabetes in response to short-term insulin-based therapy: The pivotal role of beta-cell function
Retnakaran et al. Diabetes, Obesity and Metabolism. 28 Jun 2023.
Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes
Retnakaran et al. Nature Communications. 27 Jul 2023.
Dr. Wendy Lou (CMI2 Team Grant Lead)
Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI
Pieruccini-Faria et al. Neurorehabilitation and Neural Repair. 02 Jun 2023.
Adipose Tissue and Plasma Markers Associated with HbA1c Pre- and Post-bariatric Surgery: a Cross-sectional and Cohort Study
Keshavjee et al. Obesity Surgery. 28 Jun 2023.
Adult Patients with Short Bowel Syndrome Treated with Teduglutide: A Descriptive Cohort Study
Daoud et al. Journal of Parenteral and Enteral Nutrition. 07 Jul 2023.
Dr. André Marette (CMI2 Team Grant Lead)
Large-scale metabolomic profiling and incident non-alcoholic fatty liver disease
Gagnon et al. iScience. 14 Jun 2023.
Dr. Arthur Mortha (CMI2 Team Grant Lead)
Re-investigating the origin and fates of colonic Treg cell subsets
Burrows & Mortha. Nature Reviews Immunology. 25 Jul 2023.
Dr. Roger Paredes (CMI2 Team Grant Lead)
Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study
Santos et al. Frontiers in Cellular and Infection Microbiology. 26 Jun 2023.
Dr. Jonathan Schertzer (CMI2 Team Grant Lead)
Statins activate the NLRP3 inflammasome and inhibit the Hippo pathway to promote myopathy
Robin et al. Physiology. 23 May 2023.
Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes
Rodrigues e-Lacerda et al. Biomedical Journal. 30 May 2023.
Dr. Padmaja Subbarao (CMI2 Team Grant Lead)
Lung Function as a Biomarker of Health – An Old Concept Rediscovered
Reyna et al. American Journal of Respiratory and Critical Care Medicine. 07 Jun 2023.
Dr. Michael Surette (CMI2 Team Grant Lead)
Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada
Jacob et al. Emerging Infectious Diseases. 12 Jul 2023.
Dr. Carolina Tropini (CMI2 Team Grant Lead)
An impedance-based chemiresistor for the real-time, simultaneous detection of gut microbiota-generated short-chain fatty acids
Yavarinasab et al. Sensors and Actuators B: Chemical. 30 Jun 2023.
Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota
Ng et al. mBio. 11 Jul 2023.
Dr. Stuart Turvey (CMI2 Team Grant Lead)
Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay
Mohajeri et al. Journal of Medical Genetics. 14 Jun 2023.
Dr. Bruce Vallance (CMI2 Team Grant Lead)
Sialic acid plays a pivotal role in licensing Citrobacter rodentium’s transition from the intestinal lumen to a mucosal adherent niche
Liang et al. PNAS. 03 Jul 2023.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world
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