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IMPACTT Newsletter | March 2023
Dear ,
Welcome to our March 2023 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS
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Submit Your Abstract: Having IMPACTT Symposium

Registration & abstract submissions are open for our Having IMPACTT 3: Advancing Microbiome Research Symposium, happening July 10-12, 2023 in Canmore, AB!
Speakers, sessions, and available awards have been announced! Learn more and register here.
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Register Now: IMPACTT Gnotobiotic Workshop

Our second IMPACTT Gnotobiotic Workshop on May 4-5, 2023 at the University of Calgary. Learn to set up, sterilize, and maintain a germ-free isolator, as well as plan and conduct germ-free and gnotobiotic experiments. Space is extremely limited and there are just a few spots left, so register now to secure your spot! Learn more and register here.

Register Now: CBW-IMPACTT Microbiome Analysis Workshop

IMPACTT and Bioinformatics.ca have teamed up to organize the CBW-IMPACTT Microbiome Analysis Workshop, happening July 5-7, 2023 at the University of Calgary! This is a great opportunity to learn how to analyze data gathered from microbiome experiments. Learn more and apply here.

IMPACTT Mentorship Program

Learn more about the mentees in our 2023-2024 mentorship cohort here!

IMPACTT TEAM & NETWORK NEWS
Dr. Karen Madsen (Platform 3 Lead) & Dr. Marie-Claire Arrieta (Platform 2 Co-Lead) were speakers at the Gut Microbiota for Health World Summit 2023 in Prague, Czech Republic on March 11 & 12, 2023. Dr. Madsen spoke about “Fecal Microbial Transplantation with Fiber Supplementation in the Treatment of Metabolic Syndrome and Obesity” and Dr. Arrieta spoke about “Probiotic to Accelerate Gut Microbiome Maturation in Extremely Preterm Infants”.
Dr. Kevin McGregor (IMPACTT Mentee) gave a talk at the Centre for Global Child Health at SickKids Hospital in Toronto on “Community modelling techniques in microbiome data”.

NEW PUBLICATIONS

New Publications in the Microbiome World

Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Schlechte et al. (including IMPACTT Director/Platform 1 Lead Dr. Kathy McCoy and Education & Mentorship Co-Lead Dr. Braedon McDonald) Nature Medicine. 09 Mar 2023.
Highlights: In this study, the researchers collected rectal samples and conducted single-cell profiling of systemic immune and inflammatory responses in a prospective longitudinal cohort study of critically ill patients. They found that the gut microbiota and systemic immunity function as an integrated metasystem, where dysbiosis is coupled to impaired host defense and increased frequency of nosocomial (healthcare-associated) infections.
Microbiota alters the metabolome in an age- and sex- dependent manner in mice
Brown et al. (including IMPACTT Director/Platform 1 Lead Dr. Kathy McCoy and Platform 4 Co-Lead Dr. Ian Lewis). Nature Communications. 11 Mar 2023.
Highlights: In this study, the researchers used liquid chromatography mass spectrometry to study the metabolomes of germ-free, gnotobiotic, and specific pathogen-free mice, while also evaluating the influence of age and sex on metabolite profiles. They found that microbiota and age explained similar amounts of variation in the metabolome of some samples (urine, serum, peritoneal fluid), but age was the primary driver of metabolite profile variation in the liver and spleen. Sex was a significant factor at all sites except the ileum, but explained the least amount of variation.

New Publications from our IMPACTT Team and Network

Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead)
Microbial metabolites and immunotherapy: Basic rationale and clinical indications
Kovtonyuk & McCoy. Seminars in Immunology. 27 Mar 2023.
Dr. Paul Kubes (Platform 1 Co-Lead)
Hepatic C-X-C chemokine receptor type 6–expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury
Felix et al. Hepatology Communications. 01 Apr 2023.
Dr. Celia Greenwood (Platform 5 Lead)
Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
Henry et al. Journal of Affective Disorders. 24 Mar 2023.
Dr. Braedon McDonald (Education Co-Lead)
Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol
Zhang et al. Systematic Reviews. 21 Mar 2023.
Dr. John Conly (IMPACTT Co-Applicant)
Exploring data reduction strategies in the analysis of continuous pressure imaging technology
Peng et al. BMC Medical Research Methodology. 01 Mar 2023.
Patient and ward related risk factors in a multi-ward nosocomial outbreak of COVID-19: Outbreak investigation and matched case–control study
Leal et al. Antimicrobial Resistance & Infection Control. 22 Mar 2023.
Dr. Irina Dinu (IMPACTT Co-Applicant)
Third Trimester Umbilical Arterial Pulsatility Index is Associated with Neurodevelopmental Outcomes at 2-Years in Major Congenital Heart Disease
Moray et al. Pediatric Cardiology. 11 Mar 2023.
Infants less than or equal to 2.5kg have increased mortality and worse motor neurodevelopmental outcomes at 2 years of age after Norwood-Sano palliation
Averin et al. JTCVS Open. 21 Mar 2023.
Identification of Prognostic Biomarkers for Breast Cancer Metastasis Using Penalized Additive Hazards Regression Model
Tapak et al. Cancer Informatics. 21 Mar 2023.
Dr. Jens Walter (IMPACTT Co-Applicant)
Fecal microbiota-based treatment for recurrent Clostridioides difficile infection
Walter & Shanahan. Cell. 16 Mar 2023.
Evidence for a Causal Role for Escherichia coli Strains Identified as Adherent-Invasive (AIEC) in Intestinal Inflammation
Kittana et al. mSphere. 08 Mar 2023.
A phylogenomic analysis of Limosilactobacillus reuteri reveals ancient and stable evolutionary relationships with rodents and birds and zoonotic transmission to humans
Li et al. BMC Biology. 13 Mar 2023.
Dr. Eytan Wine (IMPACTT Co-Applicant)
Novel Biomarkers for Inflammatory Bowel Disease and Colorectal Cancer: An Interplay between Metabolic Dysregulation and Excessive Inflammation
Salla et al. International Journal of Molecular Sciences. 22 Mar 2023.
Dr. Robert Beiko (IMPACTT Co-Applicant)
Suspension of oral hygiene practices highlights key bacterial shifts in saliva, tongue, and tooth plaque during gingival inflammation and resolution
Hall et al. ISME Communications. 25 Mar 2023.
Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
First-in-class Microbial Ecosystem Therapeutic 4 (MET4) in combination with immune checkpoint inhibitors in patients with advanced solid tumors (MET4-IO Trial)
Spreafico et al. Annals of Oncology. 1 Mar 2023.
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Evaluation of frameworks demonstrating the role of private sector in non-communicable disease management and control: a systematic review and thematic synthesis
Somani et al. BMJ Open. 03 Mar 2023.
Machine learning for accurate estimation of fetal gestational age based on ultrasound images
Lee et al. npj Digital Medicine. 09 Mar 2023.
Community and Health Care Provider Perspectives on Barriers to and Enablers of Family Planning Use in Rural Sindh, Pakistan: Qualitative Exploratory Study
Memon et al. JMIR Formative Research. 10 Mar 2023.
Community Mobilization and Community Incentivization (CoMIC) Strategy for Child Health in a Rural Setting of Pakistan: Study Protocol for a Randomized Controlled Trial
Das et al. Methods and Protocols. 13 Mar 2023.
Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Associations between maternal folate status and choline intake during pregnancy and neurodevelopment at 3-4 years of age in the Alberta Pregnancy Outcomes and Nutrition (APrON) study
Irvine et al. Journal of Developmental Origins of Health and Disease. 20 Mar 2023.
Dr. Jeremy Hirota (CMI2 Team Grant Lead)
Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosis
Mekhael et al. Immunology & Cell Biology. 02 Mar 2023.
Dr. Steven Kembel (CMI2 Team Grant Lead)
Soil and tree phyllosphere microbial communities differ between coniferous and broadleaf deciduous boreal forests
Rodríguez-Rodríguez et al. Plant and Soil. 02 Mar 2023.
Historical and contemporary processes drive global phylogenetic structure across geographical scales: Insights from bat communities
Pereira Braga et al. Global Ecology and Biogeography. 07 Mar 2023.
Dr. Caroline Kramer (CMI2 Team Grant Lead)
The vascular function effects of adding exenatide or meal insulin to basal insulin therapy in early type 2 diabetes
Retnakaran et al. Cardiovascular Diabetology. 09 Mar 2023.
Dr. Tony Lam (CMI2 Team Grant Lead)
A glucose-sensing mechanism with glucose transporter-1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats
Li et al. Journal of Biological Chemistry. 23 Mar 2023.
Dr. Morgan Langille (CMI2 Team Grant Lead)
Hepatotoxicity of polymeric proanthocyanidins is caused by translocation of bacterial lipopolysaccharides through impaired gut epithelium
Thilakarathna et al. Toxicology Letters. 22 Mar 2023.
Dr. Wendy Lou (CMI2 Team Grant Lead)
Local Injection for Treating Mood Disorders (LIFT-MOOD): A Pilot Feasibility RCT of Stellate Ganglion Block for Treatment-Resistant Depression
Sussman et al. Chronic Stress. 07 Mar 2023.
Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases
Riek et al. Brain Communications. 02 Mar 2023.
Dr. André Marette (CMI2 Team Grant Lead)
Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants
Navarro et al. Environments. 22 Mar 2023.
Experimental diets dictate the metabolic benefits of probiotics in obesity
Larsen et al. Gut Microbes. 21 Mar 2023.
Dr. Roger Paredes (CMI2 Team Grant Lead)
Pneumoproteins and biomarkers of inflammation and coagulation do not predict rapid lung function decline in people living with HIV
MacDonald et al. Scientific Reports. 23 Mar 2023.
Dr. Vanessa Poliquin (CMI2 Team Grant Lead)
Penicillin allergy delabelling in pregnancy
Atkinson et al. Canadian Medical Association Journal. 27 Mar 2023.
Dr. Michael Surette (CMI2 Team Grant Lead)
Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study
Johnstone et al. Journal of Critical Care. 03 Mar 2023.
Dr. Stuart Turvey (CMI2 Team Grant Lead)
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
García-García et al. Journal of Experimental Medicine. 03 March 2023.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world
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