IMPACTT Newsletter | November 2023

Dear ,

Welcome to our November 2023 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS

Having IMPACTT Symposium

Registration & abstract submissions open on Dec 1, 2023 for our Having IMPACTT 4 Symposium, which will be held June 3-5, 2024 at the Malcolm Hotel in Canmore, AB! More details are released all the time, so head to our symposium webpage to sign up for updates and we’ll make sure you don’t miss any deadlines.

IMPACTT Mentorship Program

Applications are open until Jan 31, 2024 for our IMPACTT Mentorship Program! If you’re a postdoc, research associate, or early career faculty in a microbiome-related field (or know someone who is), this is an excellent opportunity to get paired with an established researcher who can mentor you on your way to new career heights! Learn more and apply here.

IMPACTT TEAM & NETWORK NEWS

Clarivate Highly Cited Researchers 2023

The following IMPACTT team & network members who were designated Highly Cited Researchers for 2023 by Clarivate: Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead), Dr. Paul Kubes (Platform 1 Co-Lead), Dr. Jens Walter (IMPACTT Co-Applicant), Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead), and Dr. Arthur Mortha (CMI2 Team Grant Lead). Congratulations!

Canada Excellence Research Chair in Immunophysiology and Immunotherapy

Dr. Paul Kubes (Platform 1 Co-Lead) has begun a new role at Queen’s University as Canada Excellence Research Chair (CERC) in Immunophysiology and Immunotherapy. The CERC awards are among the most prestigious available gloabally. Read the announcement and the interview with Dr. Kubes in the Queen’s Gazette to learn more about his cutting-edge research. Congratulations!

JOB OPPORTUNITY

Postdoctoral Scholar in Microbiome and Child Development

The Developmental Psychobiology Lab at the University of Calgary is recruiting a postdoctoral scholar to become part of an active and innovative research program that is elucidating the links between gut microbiota, mental health, neurodevelopment, and health behaviours (sleep, diet, exercise) in children. The scholar’s work will help to identify novel and actionable intervention targets to optimize neurodevelopmental and mental health outcomes in children and adolescents. For more information about this opportunity, please see the job posting, or contact Professor Gerry Giesbrecht at [email protected].

IN THE MEDIA

Dr. Carolina Tropini (CMI2 Team Grant Lead and IMPACTT Mentor) was interviewed in The Globe and Mail about her lab’s research “investigating the roles and complex interactions of gut microbial communities to discover new therapeutics and combat diseases linked to inflammation.” Read the full article here.

NEW PUBLICATIONS

New Publications in the Microbiome World

Smoking and salivary microbiota: a cross-sectional analysis of an Italian alpine population
Antonello et al. Scientific Reports. 02 Nov 2023.
Highlights: Smoking is a risk factor for many diseases, including respiratory diseases, periodontitis, oropharyngeal cancers, and cardiovascular diseases. Changes in the oral microbiota have also been linked to diseases such as periodontitis, squamous cell carcinomas, and cardiovascular diseases. Smoking is also known to alter the oral microbiota. Therefore, in this study, researchers investigated the influence of smoking on the oral microbiota and predicted metabolic pathways. They found that the oral microbiota of “former smokers” was more similar to “never smokers” than to “current smokers”, especially if they had not smoked in more than 5 years. This included an increase in aerobic bacterial taxa relative abundance in former and never smokers as compared to current smokers, along with inferred nitrate reduction pathways, which affect blood pressure regulation.

Multi-site microbiota alteration is a hallmark of kidney stone formation
Al et al. Microbiome. 25 Nov 2023.
Highlights: Kidney stone disease has been increasing in recent years, including among historically less-affected populations such as young women and children. Previous studies have found a link between microbiota dysbiosis and kidney stone formation, but most focused on the gut microbiota. In this study, the researchers compared the gut, urinary, and oral microbiota of 83 participants who regularly produce kidney stones and 30 healthy controls. Urinary oxalate levels were lower in healthy controls compared to stone formers. The production of oxalate is implicated in the formation of kidney stones, and specific Oxalobacter spp. (such as O. formigenes) have previously been thought to play a role in protecting against kidney stone formation since they use oxalate as a sole carbon source. Stone formers and healthy controls had significantly different gut, but not oral, microbiota composition and alpha diversity. However, no differences in the relative abundance of O. formigenes were identified by whole shotgun metagenomic sequencing. The researchers suggest that the historical focus on Oxalobacter spp. may provide an incomplete picture of kidney stone disease risk.

New Publications from our IMPACTT Team and Network

Dr. Anita Kozyrskyj (Platform 2 Lead) & Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Maternal iron and vitamin D status during the 2nd trimester is associated with 3rd trimester depression symptoms among pregnant participants in the APrON cohort
Evanchuk et al. The Journal of Nutrition. 19 Nov 2023.

Dr. Wendy Lou & Dr. Padmaja Subbarao (CMI2 Team Grant Leads)
A Bayesian latent class model for integrating multi-source longitudinal data: application to the CHILD cohort study
Lu et al. Journal of the Royal Statistical Society Series C: Applied Statistics. 13 Nov 2023.

Dr. Aleixo Muise & Dr. Anne Griffiths (CMI2 Team Grant Leads)
Body surface area-based dosing of infliximab is superior to standard weight-based dosing in children with very early onset inflammatory bowel disease
Stallard et al. Gastro Hep Advances. 18 Nov 2023.

Dr. Marie-Claire Arrieta (Platform 2 Co-Lead)
The mycobiome in atopic diseases: inducers and triggers
Glatthardt et al. The Journal of Allergy and Clinical Immunology. 18 Oct 2023.

Dr. Braedon McDonald (Education Co-Lead)
Heat shock protein 27 in the pathogenesis of COVID-19 and non-COVID acute respiratory distress syndrome
Chiu et al. Cell Stress and Chaperones. 15 Nov 2023.

Dr. Diego Silva (Ethics Lead)
Ethics and Health Security in the Australian COVID-19 Context: A Critical Interpretive Literature Review
Fehross et al. Journal of Bioethical Inquiry. 08 Nov 2023.

Dr. Benjamin Willing (IMPACTT Co-Applicant)
Tracking the fecal mycobiome through the lifespan of production pigs and a comparison to the feral pig
Prisnee et al. Applied and Environmental Microbiology. 30 Oct 2023.

Dr. Eytan Wine (IMPACTT Co-Applicant)
The Crohn’s Disease Exclusion Diet: A Comprehensive Review of Evidence, Implementation Strategies, Practical Guidance, and Future Directions
Boneh et al. Inflammatory Bowel Diseases. 18 Nov 2023.

Dr. Vanessa Poliquin (CMI2 Team Grant Lead)
Insights and advances in recurrent vulvovaginal candidiasis
San Juan Galán et al. PLOS Pathogens. 10 Nov 2023.

Dr. Michael Surette (CMI2 Team Grant Lead)
Epidemiology and impact of methicillin-sensitive Staphylococcus aureus with β-lactam antibiotic inoculum effects in adults with cystic fibrosis
Svishchuk et al. Antimicrobial Agents and Chemotherapy. 15 Nov 2023.

Dr. Carolina Tropini (CMI2 Team Grant Lead)
Time to rethink academic publishing: the peer reviewer crisis
Tropini et al. mBio. 17 Nov 2023.

Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
Preparation, analysis and toxicity characterisation of the redox metabolites of the azo food dye tartrazine
Pay et al. Food and Chemical Toxicology. 26 Nov 2023.

Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Maternal Pre-Pregnancy BMI and Gestational Weight Gain Are Associated with Preschool Children’s Neuropsychological Outcomes in the APrON Cohort
England-Mason et al. Children. 25 Nov 2023.

Dr. Jeremy Hirota (CMI2 Team Grant Lead)
Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report
Vukmirovic et al. Annals of the American Thoracic Society. 30 Oct 2023.

High-Fidelity Extrusion Bioprinting of Low-Printability Polymers Using Carbopol as a Rheology Modifier
Carpio et al. ACS Applied Material Interfaces. 14 Nov 2023.

Dr. Wendy Lou (CMI2 Team Grant Lead)
Relationships between Bone Mineral Density and Antidepressant Use and Physical Activity in U.S. Adults
Li et al. University of Toronto Journal of Public Health. 30 Oct 2023.

Dr. David Mack (CMI2 Team Grant Lead)
The Benefit of Early and Frequent Antitumor Necrosis Factor-Alpha Trough Level Determination in Very Early-Onset Inflammatory Bowel Disease
Gillmore et al ACG Case Reports Journal. 03 Nov 2023.

Dr. André Marette (CMI2 Team Grant Lead)
Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia
Liu et al. The FASEB Journal. 30 Oct 2023.

The metabolic benefits of substituting sucrose for maple syrup are associated with a shift in carbohydrate digestion and gut microbiota composition in high-fat high-sucrose diet-fed mice
Morissette et al. American Journal of Physiology – Endocrinology and Metabolism. 17 Nov 2023.

Dr. Roger Paredes (CMI2 Team Grant Lead)
Vaccination with an HIV T-Cell Immunogen (HTI) Using DNA Primes Followed by a ChAdOx1-MVA Boost Is Immunogenic in Gut Microbiota-Depleted Mice despite Low IL-22 Serum Levels
Elizalde-Torrent et al. Vaccines. 30 Oct 2023.

A Randomized Trial of Dolutegravir Plus Darunavir/Cobicistat as a Switch Strategy in HIV-1-Infected Patients With Resistance to at Least 2 Antiretroviral Classes
Santos et al. Open Forum Infectious Diseases. 31 Oct 2023.

Vagus Nerve Dysfunction in the Post-COVID-19 Condition: a pilot cross sectional study
Lladós et al. Clinical Microbiology and Infection. 18 Nov 2023.

The burden of post-acute COVID-19 symptoms in a multinational network cohort analysis
Kostka et al. Nature Communications. 17 Nov 2023.

Oral and intravenous 1'-cyano-substituted adenosine-like antivirals for early COVID-19
Gottlieb & Paredes. The Lancet Infectious Diseases. 22 Nov 2023.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world

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