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IMPACTT Newsletter | August 2023
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Welcome to our August 2023 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.
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Having IMPACTT Symposium
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Details about our Having IMPACTT 2024 Symposium will be released soon. Head to our symposium page to sign up for updates so you’ll be the first to know. And thanks again to the sponsors of our 2023 symposium! If you’re interested in sponsoring our 2024 symposium, get in touch by emailing [email protected].
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IMPACTT TEAM & NETWORK NEWS
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Dr. Adriana Buzatto began a position as Assistant Professor in the Department of Biological Sciences at the University of Calgary. She will be establishing a lipidomics program to investigate the relationship between lipids and biochemical pathways, diseases, and physiological reactions. The Buzatto lab is seeking dedicated students at all levels - contact the lab for more information. Dr. Buzatto will be working closely with Dr. Ian Lewis (Platform 4 Co-Lead), who is Principal Investigator of the Calgary Metabolomics Research Facility, a Silver Sponsor of this year’s Having IMPACTT Symposium.
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Microbiome Insights, a Gold Sponsor of our Having IMPACTT 3 Symposium, published a blog post about their experience at our symposium. Read the full review here.
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NEW PUBLICATIONS
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Mucosal Immunology Highlight
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Mucosal Immunology, a Bronze Sponsor of our Having IMPACTT 3 Symposium, is the official publication of the Society for Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues. Learn more about the journal and submit an abstract here.
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New Publications in the Microbiome World
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Shaffer et al. mSystems. 23 Aug 2023.
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Highlights: In this study, the researchers set out to better understand why some infants do not develop protective responses to vaccines administered in early life. They followed 101 subjects during their first two years of life, with enrollment starting within 3 weeks of birth. Vaccines were administered at 2, 4, and 6 months, with boosters administered post 1 year. Stool and nasal samples were collected periodically for microbiome profiling and plasma/serum was collected for metabolome and proteome profiling. Blood samples were collected at 2 months, 1 year, and 2 years to measure antibody response against vaccination antigens. They found that at 2 months of age, evenness of genera in the stool microbiome samples, as well as phenylpyruvic acid abundance in serum, correlated with lower vaccine responses at 1 year of age, but no other diversity measures in stool or nasopharynx microbial communities were associated with vaccine response at any of the sampling timepoints. Antibiotic use at birth was also negatively associated with vaccine response at 1 year. These results suggest that the time from birth up to 2 months of age may be critical for future vaccine response, and the researchers suggest that targeted interventions in this window of time may be most effective.
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Liao et al. Nature Communications. 17 Aug 2023.
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Highlights: In this study, the researchers investigated the link between the maternal vaginal microbiome and preterm birth (PTB) outcomes. They analyzed the microbial communities of 40 women who experienced spontaneous PTB (705 unique samples) as well as 135 term controls. They found that the vaginal microbiome in the PTB samples was more genetically diverse at the species level, and had increased richness and diversity of antimicrobial resistance genes. They further found that Gardnerella spp. drove this higher diversity, especially in the first half of pregnancy. They also showed that Gardnerella spp. underwent more frequent recombination and stronger purifying selection in genes involved in lipid metabolism. Their results suggest that evolutionary processes acting on vaginal microbes may play a role in adverse pregnancy outcomes such as PTB.
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New Publications from our IMPACTT Team and Network
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Dr. Anne Griffiths, Dr. Michael Surette, Dr. Aleixo Muise, Dr. Bruce Vallance, Dr. David Mack (CMI2 Team Grant Leads) & Dr. Eytan Wine (IMPACTT Co-Applicant)
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Dhaliwal et al. Journal of Crohn’s and Colitis. 21 Aug 2023.
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Dr. André Marette (CMI2 Team Grant Lead) & Dr. Nicole Beauchemin (IMPACTT Co-Applicant)
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Kumar et al. Journal of Biological Chemistry. 16 Aug 2023.
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Dr. Celia Greenwood (Platform 5 Lead)
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Zhou et al. Nature Genetics. 09 Aug 2023.
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Dr. John Conly (IMPACTT Co-Applicant)
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Mitchell et al. Canada Communicable Disease Report. Jul/Aug 2023.
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Dr. Irina Dinu (IMPACTT Co-Applicant)
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Afshar et al. Heliyon. 02 Aug 2023.
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Dr. Dongyan Niu (IMPACTT Co-Applicant)
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Salah Uddin et al. Frontiers in Microbiology. Aug 2023.
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Dr. Janet Hill (IMPACTT Co-Applicant)
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Deschner et al. Microbiology Resource Announcements. 09 Aug 2023.
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Dr. Thomas Louie (IMPACTT Co-Applicant)
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Berenson et al. Clinical Infectious Diseases. 04 Aug 2023.
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Dr. Benjamin Willing (IMPACTT Co-Applicant)
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Diether et al. PLOS One. 28 Jul 2023.
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Dr. Robert Bandsma (CMI2 Team Grant Lead)
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Potani et al. PLOS One. 24 Aug 2023.
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Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
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Antimicrobial Resistance Collaborators. The Lancet Regional Health: Americas. 08 Aug 2023.
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Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
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Dewey et al. NeuroToxicology. 29 Jul 2023.
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Dr. Anne Marie Griffiths (CMI2 Team Grant Lead)
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Crowley et al. Inflammatory Bowel Diseases. 31 Jul 2023.
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Dr. Jessie Hulst (CMI2 Team Grant Lead)
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Yanchis et al. Journal of Pediatric Gastroenterology and Nutrition. 12 Jul 2023.
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Dr. Caroline Kramer (CMI2 Team Grant Lead)
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Retnakaran et al. Diabetologia. 24 Aug 2023.
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Dr. Morgan Langille (CMI2 Team Grant Lead)
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Biswas et al. Journal of Functional Foods. 19 Aug 2023.
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McCormick et al. Water Research. 21 Aug 2023.
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Dr. Arthur Mortha (CMI2 Team Grant Lead)
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Chiaranunt et al. Science Immunology. 04 Aug 2023.
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Dr. Roger Paredes (CMI2 Team Grant Lead)
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Xie et al. Nature Communications. 03 Aug 2023.
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Dr. Padmaja Subbarao (CMI2 Team Grant Lead)
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Genkin et al. Academic Radiology. 05 Aug 2023.
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Dr. Stuart Turvey (CMI2 Team Grant Lead)
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Ozgoren et al. Stem Cell Research. 28 Jul 2023.
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Vaseghi-Shanjani et al. Frontiers in Allergy. Aug 2023.
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UPCOMING EVENTS AND REMINDERS
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Click here to see curated lists of upcoming events in the microbiome world
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IMPACTT Microbiome Standards
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Our four Microbiome Standards are ready to ship across Canada and internationally, and they’re FREE for Canadian labs. (Not in Canada? Just pay shipping.) Click here to learn more and sign up to receive your standards.
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Be a contributor to our microbiome community!
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