|
IMPACTT Newsletter | July 2022
|
|
|
|
|
Welcome to our July 2022 IMPACTT newsletter! We hope you're enjoying your summer. Keep reading for news, events, and new publications in the microbiome world.
|
|
|
|
|
|
Free Resource:
Bioinformatics Workshop Videos Now Available
|
|
|
|
IN THE NEWS
|
|
|
COVID-19 Restrictions Interview with Dr. Diego Silva
Dr. Diego Silva (IMPACTT Ethics Lead) was interviewed by ABC News about the Australian government's resistance to reintroduce masking mandates amidst rising COVID-19 cases and hospitalizations. Listen to the news segment here.
|
Gut Microbiota Interview with Dr. Carolina Tropini
|
Dr. Carolina Tropini (CMI2 Team Grant Lead) was interviewed for an article in The Scientist on "Mapping the Neighborhoods of the Gut Microbiome." Read the full article here.
|
|
|
|
|
|
New IMPACTT Publication
|
Ferdous et al. (including IMPACTT Co-Applicant Dr. Irina Dinu, and Platform 5 Lead Dr. Celia Greenwood and Platform 2 Leads Dr. Anita Kozyrskyj and Dr. Marie-Claire Arrieta as lead authors). Mucosal Immunology. 22 Jul 2022.
|
|
Highlights: In this review, the authors summarize statistical approaches to calculate sample sizes for typical microbiome study scenarios, including those that hypothesize microbiome features to be the outcome, the exposure, or the mediator. This review is intended to be a resource to facilitate sample size calculations that are based on testable hypotheses across several dimensions of the microbiome, and includes relevant R scrips to conduct some of these calculations.
|
|
|
|
New Publications in the Microbiome World
|
Constante et al. (including CMI2 Team Grant Lead Dr. Michael Surette). Gastroenterology. 8 Jul 2022.
|
Highlights: Altered gut microbiota has been implicated as a risk factor for celiac disease. In this study, researchers characterized the microbiota along the GI tract of celiac disease patients and gnotobiotic mice using Illumina sequencing and predicted gene function. They determined luminal and mucosal microbial niches along the gut in celiac disease patients, and identified novel microbial proteolytic pathways involved in gluten detoxification that are impaired in celiac disease.
|
|
Leibovitzh et al. (including Platform 3 Lead Dr. Karen Madsen and CMI2 Team Grant Leads Dr. Anne Griffiths & Dr. David Mack). Gastroenterology. 16 Jul 2022.
|
Highlights: In this study, researchers aimed to assess if alterations in gut microbial composition and functional pathways were associated with gut barrier function, using a cohort of healthy first-degree relatives of patients with Crohn’s disease. They found that subjects with impaired gut barrier function had reduced alpha-diversity and altered beta-diversity as compared to subjects with normal gut barrier function. Impaired gut barrier function was also associated with eight genera and 52 microbial pathways, suggesting that the gut microbiome community and pathways are associated with changes in gut barrier function.
|
|
Bridgman et al. (including CMI2 Team Grant Leads Dr. Stuart Turvey & Dr. Padmaja Subbarao, and Platform 2 Lead Dr. Anita Kozyrskyj as lead author). International Journal of Obesity. 15 Jul 2022.
|
|
Highlights: In this prospective cohort study, researchers set out to determine associations between infant fecal gut metabolites and sIgA (measured at 3-4 months) and BMI z score (calculated at 1 and 3 years). They found that high fecal formate in infancy was associated with significantly lower BMI x score, while high butyrate was associated with higher BMI z score (at the 3 year mark only). No associations were seen between sIgA and BMI z score.
|
|
New Publications from our IMPACTT Team and Network
|
Dr. Meghan Azad, Dr. Stuart Turvey, Dr. Wendy Lou, & Dr. Padmaja Subbarao (CMI2 Team Grant Leads)
|
Reyna-Vargas et al. Nature and Science of Sleep. 5 Jul 2022.
|
|
Dr. Anita Kozyrskyj (Platform 2 Lead), Dr. Meghan Azad, Dr. Stuart Turvey, & Dr. Padmaja Subbarao (CMI2 Team Grant Leads)
|
Obiakor et al. Antibiotics. 21 Jul 2022.
|
|
Dr. Anne Griffiths & Dr. Aleixo Muise (CMI2 Team Grant Leads)
|
Crowley et al. Gastroenterology. 16 Jul 2022.
|
|
Dr. Karen Madsen (Platform 3 Lead) & Dr. Michael Surette (CMI2 Team Grant Lead)
|
De Palma et al. Science Translational Medicine. 27 Jul 2022.
|
|
Dr. Paul Kubes (Platform 1 Co-Lead)
|
Hossain et al. Nature Communications. 29 Jul 2022.
|
|
Dr. Anita Kozyrskyj (Platform 2 Lead)
|
Volker et al. Expert Review of Clinical Immunology. 19 Jul 2022.
|
|
Dr. Karen Madsen (Platform 3 Lead)
|
Wu et al. Gastro Hep Advances. 11 Jul 2022.
|
|
Dr. John Conly (IMPACTT Co-Applicant)
|
O’Grady et al. Infection Control & Hospital Epidemiology. 07 Jul 2022.
|
Hubert et al. Emerging Infectious Diseases. 22 Jul 2022.
|
Flemons et al. American Journal of Infection Control. 28 Jul 2022.
|
|
Dr. Janet Hill (IMPACTT Co-Applicant)
|
Byers et al. Emerging Infectious Diseases. 08 Jul 2022.
|
|
Dr. Jens Walter (IMPACTT Co-Applicant)
|
Peixoto et al. Nature Microbiology. 21 Jul 2022.
|
|
Dr. Benjamin Willing (IMPACTT Co-Applicant)
|
Diether & Willing. From the book: Metabolism of Nutrients by Gut Microbiota. 01 Jul 2022.
|
|
Dr. Robert Beiko (IMPACTT Co-Applicant)
|
Liu et al. Systematic Biology. 29 Jul 2022.
|
|
Dr. Robert Bandsma (CMI2 Team Grant Lead)
|
Njunge et al. Gates Open Research. 18 Jul 2022.
|
|
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
|
Giancola et al. Journal of Global Health Reports. 14 Jul 2022.
|
Soofi et al. The Lancet Regional Health – Southeast Asia
|
Haakenstad et al. The Lancet. 21 Jul 2022.
|
|
Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
|
Tomfohr-Madsen et al. Sleep Health. 21 Jul 2022.
|
|
Dr. Anne Marie Griffiths (CMI2 Team Grant Lead)
|
Focht et al. Gastroenterology. 22 Jul 2022.
|
|
Dr. Jessie Hulst (CMI2 Team Grant Lead)
|
Iping, Hulst, & Joosten. Clinical Nutrition ESPEN. 14 Jul 2022.
|
|
Dr. André Marette (CMI2 Team Grant Lead)
|
Sirvent et al. Diabetes, Obesity and Metabolism. 15 Jul 2022.
|
George et al. Antibiotics. 19 Jul 2022.
|
|
Dr. Caroline Tropini (CMI2 Team Grant Lead)
|
Tropini. Cell Host & Microbe. 13 July 2022.
|
|
Dr. Stuart Turvey (CMI2 Team Grant Lead)
|
|
Sharma et al. Blood. 5 Jul 2022.
|
|
|
|
|
UPCOMING EVENTS AND REMINDERS
|
|
|
|
|
Click here to see curated lists of upcoming events in the microbiome world
|
|
|
|
|
|
CALL FOR PAPERS
|
|
|
|
Neuropharmacology has an upcoming special issue on Microbiome & the Brain: Mechanisms & Maladies with guest editors Dr. María R. Aburto and Dr. John F. Cryan. Deadline: 1 September 2022.
|
|
|
Be a contributor to our microbiome community!
|
|
|
|
|
|
|
|
|
|
|
|
|
|
