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IMPACTT Newsletter | October 2022
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Dear ,
Welcome to our October 2022 IMPACTT newsletter! Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS
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Having IMPACTT 3 Symposium: Save The Date!

Our Having IMPACTT 3: Advancing Microbiome Research Symposium will take place July 10-12, 2023 at the Malcolm Hotel in Canmore, Canada. Click here to learn more about this exciting 2.5 day symposium that will highlight the latest microbiome research across Canada and around the world, and don’t forget to sign up for updates.
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CIHR Microbiome Strengthening Workshop

Save The Date: The CIHR Microbiome Strengthening Workshop will be held on July 13, 2023 at the Malcolm Hotel in Canmore, following the IMPACTT Symposium. This workshop is for IMPACTT Core team members and CMI2 Team Grant recipients. We look forward to seeing you there!
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IMPACTT Bioinformatics Workshop

Our Bioinformatics Workshop at McGill University in Montréal, QC on Dec 6-7, 2022 is sold out! You can add yourself to the waitlist by clicking here, or sign up for updates about future workshops by clicking here.
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IMPACTT Microbiome Standards

Our four Microbiome Standards are ready to ship across Canada and internationally, and they’re FREE for Canadian labs. (Not in Canada? Just pay shipping.) Click here to learn more and sign up to receive your standards.

IMPACTT TEAM & NETWORK NEWS
Dr. Jayne Danska (Sex & Gender Lead) was named one of Canada’s Top 100 Most Powerful Women in 2022 by WXN (Women’s Executive Network). Read more here. Congratulations!
Dr. Laura Sycuro (Platform 4 Lead, Principal Investigator), along with Dr. Davide Martino and Dr. Ramon Cortez (co-applicants, University of Calgary) received a research grant from the Scottish Rite Charitable Foundation of Canada. The award is entitled Contribution of the gut microbiome to symptoms spanning distinct neurodevelopmental disorders in children. Congratulations!
Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead) presented a talk on “The role of the microbiome and microbial-derived metabolites in immune regulation” at the 10th International Conference on Autoimmunity: Mechanisms and Novel Treatments in Philadelphia, USA.
Dr. Markus Geuking (Education Lead) presented a talk on how “The maternal microbiota shapes susceptibility to Type 1 Diabetes” at the 10th International Conference on Autoimmunity: Mechanisms and Novel Treatments in Philadelphia, USA.
Dr. Heather Armstrong (IMPACTT Mentee) gave a keynote plenary lecture at the 16th International Hydrocolloids Conference in Guelph, ON, titled “Rethinking dietary fibre in inflammatory bowel disease: when something we thought was always good might not be good for all.” Additionally, she participated in a number of press interviews related to her recent publication in Gastroenterology, on KCBS Radio San Francisco, Study Finds, CTV Morning Live, University of Alberta Folio, and MedPage Today.

NEW PUBLICATIONS

New Publications in the Microbiome World

Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao et al. Science. 28 Oct 2022.
Highlights: Inflammatory bowel disease (IBD) increases the risk of colorectal cancer (CRC), and members of the gut microbiota can also produce small-molecule genotoxins that exacerbate this risk. Morganella morganii is enriched in the gut microbiota of both IBD and CRC patients, and in this study, researchers discovered that it produces indolimines, which are small-molecule genotoxins that can cause DNA damage. They used a gnotobiotic mouse model of colon cancer and found that indolimine-producing M. morganii increased colonic tumour burden, but a mutant form of M. morganii that was unable to produce indolimine did not. The results suggest that indolimines may contribute to intestinal tumorigenesis.
Depression and fatigue in active IBD from a microbiome perspective—a Bayesian approach to faecal metagenomics
Thomann et al. BMC Medicine. 17 Oct 2022.
Highlights: Depression and fatigue are considered common extraintestinal symptoms of inflammatory bowel disease (IBD), particularly during active disease. In this study, researchers set out to investigate whether associations exist between taxonomic and functional microbiota profiles, and severity of depression and fatigue symptoms in 62 patients with active IBD. They found that depression and fatigue were associated with lower abundance of short-chain fatty acid production and distinct pathways involving glycan, carbohydrate, and amino acid metabolism. They also found 3 bacterial genera associated with depression, and 4 genera associated with fatigue. Their results suggest that microbiota-directed therapeutic approaches in IBD patients could result in alterations of extraintestinal symptoms.

New Publications from our IMPACTT Team and Network

Dr. Heather Armstrong (IMPACTT Mentee), Dr. Jens Walter, Dr. Eytan Wine (IMPACTT Co-Applicants), & Dr. Karen Madsen (Platform 3 Lead)
Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients
Armstrong et al. Gastroenterology. 29 Sep 2022.
Dr. Robert Beiko (IMPACTT Co-Applicant), Dr. William Hsiao, & Dr. Fiona Brinkman (Platform 5 Co-Leads)
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
Alcock et al. Nucleic Acids Research. 20 Oct 2022.
Dr. Padmaja Subbarao & Dr. Stuart Turvey (CMI2 Team Grant Leads)
Development of a predictive algorithm to identify pre-school children at risk for behavior changes associated with sleep-related breathing disorders
Ezeugwu et al. Sleep Medicine. 15 Oct 2022.
Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study
Tun et al. PLOS One. 06 Oct 2022.
Dr. Meghan Azad, Dr. Stuart Turvey, Dr. Padmaja Subbarao (CMI2 Team Grant Leads), Dr Fiona Brinkman (Platform 5 Co-Lead), & Dr. Anita Kozyrskyj (Platform 2 Lead)
From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants
Bedard et al. Children. 27 Sep 2022.
Dr. Wendy Lou, Dr. Meghan Azad, Dr. Stuart Turvey, & Dr. Padmaja Subbarao (CMI2 Team Grant Leads)
Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma
Reyna et al. JAMA Network Open. 06 Oct 2022.
Dr. Karen Madsen (Platform 3 Lead)
A randomized controlled trial of a multicomponent online stress reduction intervention in inflammatory bowel disease
Peerani et al. Therapeutic Advances in Gastroenterology. Oct 2022.
Dr. Celia Greenwood (Platform 5 Lead)
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
Butler-Laporte et al. Clinical Proteomics. 28 Sep 2022.
Dr. Nicole Beauchemin (IMPACTT Co-Applicant)
Structural analysis of human CEACAM1 oligomerization
Gandhi et al. Communications Biology. 30 Sep 2022.
Dr. John Conly (IMPACTT Co-Applicant)
A Two-Ward Acute Care Hospital Outbreak of SARS-CoV-2 Delta Variant Including a Point-Source Outbreak Associated with the Use of a Mobile Vital Signs Cart and Sub-Optimal Doffing of Personal Protective Equipment
O’Grady et al. The Journal of Hospital Infection. 01 Oct 2022.
Collaborative co-design and development of a smartphone application to promote veterinary antimicrobial stewardship
Jelinski et al. The Canadian Veterinary Journal. Oct 2022.
Transmission of SARS-CoV-2 Associated with Cruise Ship Travel: A Systematic Review
Rosca et al. Tropical Medicine and Infectious Disease. 09 Oct 2022.
Dr. Irina Dinu (IMPACTT Co-Applicant)
Evaluating the Prevalence and Factors Associated with an Optimal Neurodevelopmental Outcome in 4-6 Year-Old Children with Fontan Circulation
Khoury et al. Canadian Journal of Cardiology. 28 Oct 2022.
Dr. Janet Hill (IMPACTT Co-Applicant)
Experimental natural transmission (seeder pig) models for reproduction of swine dysentery
Parra-Aguirre et al. PLOS One. 27 Sep 2022.
Combining deep sequencing and conventional molecular approaches reveals broad diversity and distribution of fleas and Bartonella in rodents and shrews from Arctic and Subarctic ecosystems
Buhler et al. Parasites & Vectors. 13 Oct 2022.
Dr. Thomas Louie (IMPACTT Co-Applicant)
Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial
Cohen et al. JAMA. 19 Oct 2022.
Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection
Khanna et al. Drugs. 26 Oct 2022.
Dr. Benjamin Willing (IMPACTT Co-Applicant)
Low-fat dairy consumption improves intestinal immune function more than high-fat dairy in a diet-induced swine model of insulin resistance
She et al. European Journal of Nutrition. 05 Oct 2022.
Dietary benzoic acid and supplemental enzymes alter fibre-fermenting taxa and metabolites in the cecum of weaned pigs
Diether et al. Journal of Animal Science. 07 Oct 2022.
Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
Impact of food preservatives based on immobilized phenolic compounds on an in vitro model of human gut microbiota
Ruiz-Rico et al. Food Chemistry. 25 Sep 2022.
Dr. Robert Bandsma (CMI2 Team Grant Lead)
Neurodevelopment and Recovery From Wasting
Babikako et al. Pediatrics. 04 Oct 2022.
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019
Haakenstad et al. The Lancet Global Health. 06 Oct 2022.
Micronutrient deficiencies among preschool-aged children and women of reproductive age worldwide: a pooled analysis of individual-level data from population-representative surveys
Stevens et al. The Lancet Global Health. 11 Oct 2022.
Mental Health Interventions in Adolescence
Campisi et al. Current Opinion in Psychology. 15 Oct 2022.
Growth Faltering in Small and Sick Newborn Infants: Does it Matter?
Bhutta. Indian Pediatrics. 01 Oct 2022.
Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Romantic Relationship Quality and Mental Health in Pregnancy During the Covid-19 Pandemic
Xie et al. Journal of Social and Clinical Psychology. Oct 2022.
Dr. Anne Marie Griffiths (CMI2 Team Grant Lead)
Development of a multimodal machine-learning fusion model to non-invasively assess ileal Crohn’s disease endoscopic activity
Guez et al. Computer Methods and Programs in Biomedicine. 31 Oct 2022.
Dr. Caroline Kramer (CMI2 Team Grant Lead)
The metabolic effects of adding exenatide to basal insulin therapy when targeting remission in early type 2 diabetes in a randomized clinical trial
Retnakaran et al. Nature Communications. 16 Oct 2022.
Dr. Wendy Lou (CMI2 Team Grant Lead)
Effect of faecal microbial transplant via colonoscopy in patients with severe obesity and insulin resistance: A randomized double-blind, placebo-controlled Phase 2 trial
Ghorbani et al. Diabetes, Obesity & Metabolism. 14 Oct 2022.
Comparison of Diffusion Tensor Imaging Metrics in Normal-Appearing White Matter to Cerebrovascular Lesions and Correlation with Cerebrovascular Disease Risk Factors and Severity
Haddad et al. International Journal of Biomedical Imaging. 21 Oct 2022.
Dr. André Marette (CMI2 Team Grant Lead)
Identification of Gastrointestinal Digestion Stable Antihypertensive Fish Peptides from Atlantic Mackerel (Scomber scombrus)
Hokmabadinazhad et al. Journal of Medicinal Food. 13 Oct 2022.
Dr. Thomas Murooka (CMI2 Team Grant Lead)
MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells
Bellini et al. iScience. 21 Oct 2022.
Dr. Roger Paredes (CMI2 Team Grant Lead)
2022 Update of the Drug Resistance Mutations in HIV-1
Wensing et al. International Antiviral Society – USA. 26 Sep 2022.
Limited Humoral and Specific T-Cell Responses After SARS-CoV-2 Vaccination in PWH With Poor Immune Reconstitution
Benet et al. The Journal of Infectious Diseases. 06 Oct 2022.
Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial
Bailón et al. Nature Medicine. 27 Oct 2022.
Dr. Jonathan Schertzer (CMI2 Team Grant Lead)
Dietary sugar lowers immunity and microbiota that protect against metabolic disease
Fang et al. Cell Metabolism. 04 Oct 2022.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world
The Antimicrobial Resistance One Health Consortium is hosting a One Health Approach Seminar Series on Antimicrobial Resistance from 04 Oct 2022 to 13 Dec 2022. For more details and to register, click here.

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