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IMPACTT Newsletter | September 2022
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Welcome to our September 2022 IMPACTT newsletter! Keep reading for news, events, and publications in the microbiome world.
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Having IMPACTT 3 Symposium: Save The Date!
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SAVE THE DATE! Our Having IMPACTT 3: Advancing Microbiome Research Symposium will take place July 10-12, 2023 at the Malcolm Hotel in Canmore, Canada. Click here to learn more about this exciting 2.5 day symposium that will highlight the latest microbiome research across Canada and around the world, and don’t forget to sign up for updates.
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Upcoming IMPACTT Bioinformatics Workshop
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SAVE THE DATE! Our Bioinformatics Workshop is back! We will be hosting a 2 day in-person bioinformatics workshop at McGill University in Montréal, QC on Dec 6-7, 2022. Registration opens very soon; to stay up-to-date on everything workshop-related, click here and sign up for updates.
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IMPACTT Microbiome Standards
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Our four Microbiome Standards are ready to ship across Canada and internationally, and they’re FREE for Canadian labs. (Not in Canada? Just pay shipping.) Click here to learn more and sign up to receive your standards.
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IMPACTT TEAM & NETWORK NEWS
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Dr. Markus Geuking (Education Lead) and Dr. Simon Hirota (co-applicant) received a Crohn’s and Colitis Canada 2022 Grant-in-Aid of Research. They will investigate how shared antigenic structures between the intestinal microbes and systemic viral infections affect colitis. Read more about it here. Congratulations!
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Dr. Anita Kozyrskyj (Platform 2 Lead) had three students present their research at the Developmental Origins of Health and Disease (DOHaD) World Congress 2022 in Vancouver, Canada. Maryam Paraktoon (MSc student) gave an oral presentation on “Pre-eclampsia, emergency cesarean delivery and Bifidobacterium levels in infant gut microbiota”; Sabrin Bashar (PhD student) gave a poster presentation on the “Impact of prolonged hospitalization on the development of the gut microbiome”; and Nicole Rodriguez (MSc student) gave a poster presentation on “Sex-specific associations among infant food and atopic sensitizations and infant socio-emotional development”.
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New IMPACTT Publication
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Thomson et al. (with IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy as senior author). Mucosal Immunology. 05 Sep 2022.
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Highlights: This IMPACTT review discusses the different approaches used to modulate microbial complexity that are available to study host-microbe interactions, and describes how different mouse models have been used to answer distinct biological questions, covering the entire microbial spectrum, from germ-free to wild.
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New Publications in the Microbiome World
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Daoust et al. (including CMI2 Team Grant Lead Dr. André Marette as senior author). Gut. 02 Sep 2022.
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Highlights: In this study, researchers compared the impact of two housing conditions (gnotobiotic-axenic vs specific-pathogen free [SPF]) on the metabolic outcomes of germ-free mice that received fecal microbiota transplantation (FMT). They found that the mice housed under gnotobiotic-axenic conditions showing decreased liver weight and hepatic triglyceride accumulation compared with the control group, while the mice housed under SPF conditions showed an opposite outcome, with exacerbated liver steatosis. These results suggest that housing conditions play a large role in influencing gut microbiota composition and function post-FMT, which can lead to different phenotypes, and the authors recommend better standardization of FMT experiments to ensure reproducibility and translatable results.
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Ianiro et al. Nature Medicine. 15 Sep 2022.
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Highlights: In this meta-analysis, researchers compared stool microbiomes from fecal microbiota transplantation (FMT) studies with publicly available data that used shotgun metagenomics, resulting in a total of 1,371 samples across 24 cohorts and multiple diseases. They found that FMT recipients were more likely to experience clinical success when donor strain engraftment was higher, and that on average Bacteroidetes and Actinobacteria species had higher engraftment than Firmicutes species. Using cross-dataset machine learning, they were able to predict donors that might lead to better post-FMT outcomes.
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Dekkers et al. Nature Communications. 23 Sep 2022.
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Highlights: In this cross-sectional study, researchers characterized the gut microbiota and plasma metabolome of 8583 participants aged 50-64, using deep metagenomic sequencing and ultra-high performance liquid chromatography linked with mass spectrometry. They found that the gut microbiota was able to explain up to 85% of the variance of individual plasma metabolites. They created an online resource (GUTSY Atlas) describing 997 associations between alpha diversity and plasma metabolites, as well as 546,819 associations between specific gut metagenomic species and plasma metabolites, including novel associations between external factors and the gut microbiome. This resource can be used as the basis for future studies targeting the link between the microbiota and plasma metabolites.
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New Publications from our IMPACTT Team and Network
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Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead) & Dr. Markus Geuking (Education Lead)
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Song-Zhao et al. Journal of the American Academy of Dermatology. 01 Sep 2022.
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Dr. Michael Surette (CMI2 Team Grant Lead) & Dr. John Conly (IMPACTT Co-Applicant)
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Izydorczyk et al. Scientific Reports. 21 Sep 2022.
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Dr. Anita Kozyrskyj (Platform 2 Lead), & Dr. Padmaja Subbarao & Dr. Stuart Turvey (CMI2 Team Grant Leads)
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Lee-Sarwar et al. Allergy. 15 Sep 2022.
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Dr. Karen Madsen (Platform 3 Lead)
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Watt et al. Crohn’s & Colitis 360. 21 Sep 2022.
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Dr. Diego Silva (Ethics Lead)
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Silva. Public Health Ethics. 06 Sep 2022.
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Silva & Smith. Asian Bioethics Review. 10 Sep 2022.
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Dr. John Conly (IMPACTT Co-Applicant)
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Hubert et al. Emerging Infectious Diseases. 16 Sep 2022.
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Dr. Dongyan Niu (IMPACTT Co-Applicant)
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Bumunang et al. Toxins. 31 Aug 2022.
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Bumunang et al. Phage. 20 Sep 2022.
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Dr. Janet Hill (IMPACTT Co-Applicant)
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Younes et al. The Canadian Veterinary Journal. 01 Sep 2022.
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Dr. Thomas Louie (IMPACTT Co-Applicant)
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Khanna et al. Antibiotics. 10 Sep 2022.
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Dr. Jens Walter (IMPACTT Co-Applicant)
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Seethaler et al. The American Journal of Clinical Nutrition. 02 Sep 2022.
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Dr. Eytan Wine (IMPACTT Co-Applicant)
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Verburgt et al. Journal of Crohn’s and Colitis. 15 Sep 2022.
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Hudson et al. Journal of Pediatric Gastroenterology and Nutrition. 20 Sep 2022.
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Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
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Ruiz-Rico et al. Food Research International. 02 Sep 2022.
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Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
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Frostad et al. The Lancet Global Health. 13 Sep 2022.
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Jiang et al. Nature Reviews Endocrinology. 15 Sep 2022.
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Singh et al. eClinicalMedicine. 18 Sep 2022.
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De Kat et al. Pregnancy Hypertension. 27 Sep 2022.
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Kalbarczyk et al. Social Science & Medicine. 20 Sep 2022.
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Liu et al. The American Journal of Clinical Nutrition. 21 Sep 2022.
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Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
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Xie et al. Trials. 05 Sep 2022.
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Dr. Anne Marie Griffiths (CMI2 Team Grant Lead)
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Scarallo & Griffiths. Nature Reviews Gastroenterology & Hepatology. 16 Sep 2022.
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Croft et al. Journal of Crohn’s and Colitis. 21 Sep 2022.
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Dr. Kelly McNagny (CMI2 Team Grant Lead)
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Kabil et al. Frontiers in Immunology. 16 Aug 2022.
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Dr. Roger Paredes (CMI2 Team Grant Lead)
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Barkauskas et al. Annals of Internal Medicine. 09 Aug 2022.
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Dr. Vanessa Poliquin (CMI2 Team Grant Lead)
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Boodman et al. Canadian Journal of Public Health. 06 Sep 2022.
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Dr. Michael Surette (CMI2 Team Grant Lead)
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Thornton et al. Journal of Pediatric Infectious Diseases Society. 07 Sep 2022.
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Dr. Caitlin Simopoulos (IMPACTT Mentee)
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Simopoulos et al. mSystems. 11 Aug 2022.
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UPCOMING EVENTS AND REMINDERS
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Click here to see curated lists of upcoming events in the microbiome world
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Be a contributor to our microbiome community!
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