IMPACTT Newsletter | November 2021

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Dear ,

Welcome to our November 2021 newsletter. Check out our updates from IMPACTT, recent publications, and upcoming events you won't want to miss out on!

IMPACTT TEAM & NETWORK NEWS

Dr. Paul Kubes (Platform 1 Co-Lead) gave a seminar at Global Immunotalks on 10 November, 2021 titled 'Why would a neutrophil biologist want to study macrophages?' If you missed it, you can watch the recording on YouTube.

Dr. Kelly McNagny was awarded a 2021 Michelle Harkness Mentorship Excellence Award (MHMA) for an established academic researcher. Congratulations, Dr. McNagny!

Dr. Meghan Azad was named one of Canada's Top 40 Under 40 by Caldwell and PWC for her research on breastfeeding and lactation. Congratulations, Dr. Azad!

PEOPLE ARE TALKING ABOUT

Dr. John Conly was interviewed by CTV News Calgary and the Calgary Harold about Firstline, a new veterinary app developed at the University of Calgary that aims optimize the use of antibiotics in animals to help reduce antimicrobial resistance.

NEW PUBLICATIONS

New Publications in the Microbiome World

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome
Lam et al. Cell Reports. 2 November 2021
Highlights: In this study, researchers used CRISPR-Cas9 to manipulate the genomes of E. coli bacteria living within mouse gastrointestinal (GI) tracts via engineered bacteriophage. The researchers hope this proof-of-concept study will lead to targeted therapeutic approaches that are species- or even strain-specific in the future.

Autism-related dietary preferences mediate autism-gut microbiome associations
Yap et al. Cell. 11 November 2021
Highlights: This new study challenges the popular hypothesis that the gut microbiome causally contributes to autism spectrum disorder (ASD). In this study, researchers performed a stool metagenomics study on 247 samples from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project, and found "negligible direct associations between ASD diagnosis and the gut microbiome." Instead, the researchers suggest that restricted diet preferences associated with ASD may lead to lower microbial diversity.

Microbiome stability and structure is governed by host phylogeny over diet and geography in woodrats (Neotoma spp.)
Weinstein et al. PNAS. 23 November 2021
Highlights: In this study, researchers characterized the diets and microbiomes of wild woodrats belonging to 7 species of the genus Neotoma located across the southwestern United States. They then brought some of these wild animals into captivity to determine how captivity altered their microbiomes. They found that in nature, geography, diet, and species explained approximately 50% of the observed microbiome variation among the population. In captivity, microbiome composition changed, but this change was species-specific, highlighting the importance of genetics in determining microbiome composition.

New Publications from our IMPACTT Team

Dr. Paul Kubes (Platform 1 Co-Lead)
Imaging α-GalCer-activated iNKT cells in a hepatic metastatic environment.
Babes, Shim, & Kubes. Cancer Immunology Research. 16 Nov 2021.

Imaging reveals novel innate immune responses in lung, liver, and beyond.
Neupane & Kubes. Immunological Reviews. 23 Nov 2021.

Dr. Fiona Brinkman (Platform 5 Co-Lead)
Chapter Two - The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary
celebration
Brinkman et al. Advances in Microbial Physiology. 16 Nov 2021.

Dr. Braedon McDonald (Education & Mentorship Co-Lead)
Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During
Severe Influenza Infection
Kim et al. Frontiers in Immunology. 11 Nov 2021.

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-
19
Sinha et al. Nature Medicine. 15 Nov 2021.

Dr. Jayne Danska (Sex & Gender Lead)
Bad to the bone: B cell acute lymphoblastic leukemia cells mediate bone destruction
Rajakumar & Danska. Molecular & Cellular Oncology. 6 Nov 2021.

UPCOMING EVENTS AND REMINDERS

Click here to see a list of upcoming events in the microbiome world.

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The IMPACTT Mentorship Program is now accepting applications for our 2022-2023 cohort. Click here to learn more about our program and apply today!


Application Deadline: 31 January, 2022
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Remember to save the date for our second annual Having IMPACTT: Advancing Microbiome Research symposium on 2 & 3 June, 2022 at the Malcolm Hotel in Canmore, AB.

CALL FOR PAPERS

Microbial Pathogenesis has a call for papers in collaboration with Current Research in Microbial Sciences and Current Research in Immunology for a special collection called Advances in Microbial Pathogenesis and Host Immunity. Deadline: 31 Dec, 2021.

MDPI is planning a special edition on Probiotics, Prebiotics and Postbiotics in Human Health. Topic editors include IMPACTT mentee Dr. Leyuan Li. Deadline: 31 Mar, 2022.

Be a contributor to our microbiome community!

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