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IMPACTT Newsletter | March 2022
Symposium_Early_Bird_Registration
Dear ,
Welcome to our March 2022 newsletter. We have a lot of exciting announcements and upcoming events you won't want to miss out on, so let's dive in!

IMPACTT TEAM & NETWORK NEWS

Having IMPACTT 2: Advancing Microbiome Research Symposium

Early-bird registration and abstract submissions close on 15 April 2022, so don't miss out! June 2-3, 2022 at the Malcolm Hotel in Canmore, AB. Click here for more details, speaker lineup, program, registration, and abstract submission!

IMPACTT/IMC Bioinformatics Workshop

Spaces are available for our Bioinformatics Workshop on May 30 - June 1, 2022 at the University of Calgary on a first-come, first-served basis. Click here for details and registration.

Dr. Kathy McCoy Awarded CSI Investigator Award

IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy was awarded the Canadian Society for Immunology's 2022 Investigator Award. The CSI Investigator Award recognizes a member for excellence in research over their career. Congratulations, Dr. McCoy!

NEW PUBLICATIONS

New Publications in the Microbiome World

Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation
Vicentini et al. (including Platform 4 Co-Lead Dr. Ian Lewis and CMI2 Team Lead Dr. Michael Surette). Brain, Behavior, and Immunity. 05 Mar 2022.
Highlights: Patients with inflammatory bowel disease (IBD) often have cognitive, emotional, and behavioural comorbidities, but the link between them is not well understood. In this study, researchers tested the hypothesis that alterations in the intestinal microbiota associated with intestinal inflammation would contribute to the development of behavioural abnormalities in male mouse models of colitis. They observed that the expression of colitis-like inflammation was accompanied by an increase in anxiety-like behaviour and changes in gut microbiota composition. Fecal microbiota transfers from these colitis models to germ-free mice induced the same behavioural changes, even in the absence of intestinal inflammation, suggesting that changes in the gut microbiota composition play an important role in behavioural changes in colitis.
A faecal microbiota signature with high specificity for pancreatic cancer
Kartal et al. Gut. 08 Mar 2022.
Highlights: In this study, researchers tested fecal and salivary microbiota as potential diagnostic markers for pancreatic cancer. They found that fecal metagenomic classifiers worked better than saliva-based classifiers, and were able to identify patients with pancreatic ductal adenocarcinoma (PDAC) with up to 84% accuracy. This accuracy increased to 94% when they combined the fecal metagenomic classifier with an analysis of carbohydrate antigen levels in serum. They conclude that this type of non-invasive screening for PDAC is feasbile.
Dietary fiber combinations to mitigate the metabolic, microbial, and cognitive imbalances resulting from diet-induced obesity in rats
Noye Tuplin et al. (including IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy). The FASEB Journal. 28 Mar 2022.
Highlights: Dietary fibre may offset some of the negative effects of a high-fat/sucrose diet. In this study, researchers fed a variety of diets, some containing different types of fibre, to diet-induced obese rats to find out if these fibres could alter the obese phenotype. Only one of the fibre treatments (beta-glucan) was able to improve glucose tolerance, highlighting the fact that different fibre types can have different effects. Fecal microbiota transplants from fibre-treated rats into germ-free mice were also performed, which did not alter body composition in the recipient mice but did result in a higher abundance of Bacteroides in some fibre-treated groups.
Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways
Dang et al. (with Platform 3 Lead Dr. Karen Madsen as senior author). Gut Microbes. 22 Mar 2022.
Highlights: In this study, researchers investigated the microbial, metabolomic, and inflammatory changes that follow two types of bariatric surgery: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). RYGB led to significant alterations in the gut microbiota, including decreased alpha-diversity and lower relative abundance of Firmicutes; these alterations were accompanied by lower inflammation and significant weight loss. In contrast, SG patients did not have any alteration in alpha-diversity, and only small changes in relative abundance of some genera. This research identified several pathways that are associated with beneficial metabolic effects of surgery, within the first 9 months post-surgery.

New Publications from our IMPACTT Team and Network

Dr. Celia Greenwood (Platform 5 Lead)
eP180: Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases
Lu & Greenwood. Genetics in Medicine. 01 Mar 2022.
Dr. Marie-Claire Arrieta (Platform 2 Co-Lead)
Multi-strain probiotics for extremely preterm infants: a randomized controlled trial
Alshaikh et al. Pediatric Research. 21 Mar 2022.
Dr. John Conly (IMPACTT Co-Applicant)
Antimicrobial use in Canadian acute-care hospitals: Findings from three national point-prevalence surveys between 2002 and 2017
Liang et al. Infection Control & Hospital Epidemiology. Mar 2022.
Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities 2 Revealed by Wastewater Monitoring
Hubert et al. MedRxiv Preprint. 10 Mar 2022.
Hospital and Long-Term Care Facility Environmental Service Workers' Training, Skills, Activities, and Effectiveness in Cleaning and Disinfection: A Systematic Review
Thomas et al. Journal of Hospital Infection. 18 Mar 2022.
Dr. Adam Burgener (CMI2 Team Grant Lead)
The Effect Of Contraception On Genital Cytokines In Women Randomized To Copper Intrauterine Device, Intramuscular Depot Medroxyprogesterone Acetate Or Levonorgestrel Implant
Tanko et al. The Journal of Infectious Diseases. 09 Mar 2022.
Gut-derived bacterial toxins impair memory CD4 T-cell mitochondrial function in HIV-1 infection
Ferrari et al. The Journal of Clinical Investigation. 22 Mar 2022.
Dr. Andre Marette (CMI2 Team Grant Lead)
Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice
Daniel et al. Nature Communications. 15 Mar 2022.
Beneficial effects of fish and fish peptides on main metabolic syndrome associated risk factors: Diabetes, obesity and lipemia
Abachi et al. Critical Reviews in Food Science and Nutrition. 17 Mar 2022.
Dr. Dongyan Niu (IMPACTT Co-Applicant)
Screening of Pig-Derived Zearalenone-Degrading Bacteria through the Zearalenone Challenge Model, and Their Degradation Characteristics
Yang et al. Toxins. 18 Mar 2022.
Dr. Anne Griffiths (CMI2 Team Grant Lead)
Mucus sialylation determines intestinal host-commensal homeostasis
Yao et al. Cell. 17 Mar 2022.
Canadian Consensus Statements on the Transition of Adolescents and Young Adults with Inflammatory Bowel Disease from Pediatric to Adult Care: A Collaborative Initiative Between the Canadian IBD Transition Network and Crohn’s and Colitis Canada
Fu et al. Journal of the Canadian Association of Gastroenterology. 26 Mar 2022.
Dr. Meghan Azad, Dr. Padmaja Subbarao, & Dr. Stuart Turvey (CMI2 Team Grant Leads)
DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study
Akhabir et al. BMC Genomics. 19 Mar 2022.
Dr. Meghan Azad (CMI2 Team Grant Lead)
Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior
de Weerth et al. Critical Reviews in Food Science and Nutrition. 30 Mar 2022.
Dr. Wendy Lou (CMI2 Team Grant Lead)
Pretreatment anxious depression as a predictor of side effect frequency and severity in escitalopram and aripiprazole adjunctive therapy
Espinola et al. Brain and Behavior. 01 Mar 2022.
Characteristics of the Ontario Neurodegenerative Disease Research Initiative Cohort
Sunderland et al. Alzheimer's & Dementia. 30 Mar 2022.
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Diabetes in Pakistan: addressing the crisis
Bhutta et al. The Lancet Diabetes & Endocrinology. 28 Mar 2022.

Tackling Protein-Calorie Malnutrition during World Crises
Padhani et al. Annals of Nutrition and Metabolism. 17 Mar 2022.
Optimal iron content in ready-to-use therapeutic foods for the treatment of severe acute malnutrition in the community settings: a protocol for the systematic review and meta-analysis
Imdad et al. BMJ Open. 09 Mar 2022.
Optimizing prevention and community-based management of severe malnutrition in children
Bhutta. PLOS Medicine. 1 Mar 2022.
Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: An epigenome-wide association study
England-Mason et al. Environmental International. 21 Mar 2022.
Dr. Jeremy Hirota (CMI2 Team Grant Lead)
Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates
Rajasekar et al. Lab on a Chip. 31 Mar 2022.
Dr. Jessie Hulst (CMI2 Team Grant Lead)
A Practical Approach to Identifying Pediatric Disease-Associated Undernutrition: A Position Statement from the ESPGHAN Special Interest group on Clinical Malnutrition
Hulst et al. Journal of Pediatric Gastroenterology and Nutrition. 03 Mar 2022.
Dr. David Mack (CMI2 Team Grant Lead)
Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopy Facilities: A Joint NASPGHAN/ESPGHAN Guideline
Lightdale et al. Journal of Pediatric Gastroenterology and Nutrition. 16 Mar 2022.
Dr. Kelly McNagny (CMI2 Team Grant Lead)
Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne muscular dystrophy pathology in mdx mice
Theret et al. Development. 25 Mar 2022.
Dr. Arthur Mortha (CMI2 Team Grant Lead)
NLRP1B and NLRP3 Control the Host Response following Colonization with the Commensal Protist Tritrichomonas musculis
Chiaranunt et al. The Journal of Immunology. 07 Mar 2022.
Dr. Aleixo Muise (CMI2 Team Grant Lead)
Platelet VPS16B is dependent on VPS33B expression, as determined in two siblings with arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome
Penon-Portmann et al. Journal of Thrombosis and Haemostasis. 24 Mar 2022.
Mucus sialylation determines intestinal host-commensal homeostasis
Yao et al. Cell. 31 Mar 2022.
Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses
Ghalandary et al. Scientific Reports. 10 Mar 2022.
Dr. Roger Paredes (CMI2 Team Grant Lead)
Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome
Oriol-Tordera et al. eBioMedicine. 21 Mar 2022.
Dr. Jonathan Schertzer (CMI2 Team Grant Lead)
Determining the metabolic impact of postbiotics in mice
Anhe et al. STAR Protocols. 18 Mar 2022.
Life-long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents
Anhe et al. Physiological Reports. 05 Mar 2022.
Dr. Carolina Tropini (CMI2 Team Grant Lead)
The CIAMIB: a Large and Metabolically Diverse Collection of Inflammation-Associated Bacteria from the Murine Gut
Wong et al. mBio. 10 Mar 2022.
Dr. Bruce Vallance (CMI2 Team Grant Lead)
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
Zindl et al. Immunity. 08 Mar 2022.
Dr. Eytan Wine (IMPACTT Co-Applicant)
Defining Transition Success for Young Adults with Inflammatory Bowel Disease According to Patients, Parents and Health Care Providers
Bihari et al. Journal of the Canadian Association of Gastroenterology. 29 Mar 2022.
Dr. Jens Walter (IMPACTT Co-Applicant)
Metagenomic strain detection with SameStr: identification of a persisting core gut microbiota transferable by fecal transplantation
Podlesny et al. Microbiome. 25 Mar 2022.
Association between gut colonization of vancomycin-resistant enterococci and liver transplant outcomes
Chiang et al. Transplant Infectious Disease. 05 Mar 2022.
Dr. Janet Hill (IMPACTT Co-Applicant)
cpn60 barcode sequences accurately identify newly defined genera within the Lactobacillaceae
Shukla & Hill. Canadian Journal of Microbiology. 01 Mar 2022.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world.
The Malcolm Hotel

Click the link to register for our second annual Having IMPACTT: Advancing Microbiome Research symposium on 2 & 3 June, 2022 at the Malcolm Hotel in Canmore, AB.
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Click the link to stay learn more and stay updated about our IMPACTT/IMC Bioinformatics Workshop on May 30 - June 1, 2022 at the University of Calgary

CALL FOR PAPERS
Neuropharmacology has an upcoming special issue on Microbiome & the Brain: Mechanisms & Maladies with guest editors Dr. María R. Aburto and Dr. John F. Cryan. Deadline: 1 September 2022.

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