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IMPACTT Newsletter | April-Mai 2021
Dear Dr. reader,
Our microbiome symposium is happening in less than two weeks! In this Newsletter, you will find some of our latest event updates as well news from our network of microbiome experts, from celebrations to resources such as new discoveries and reviews about the role of our microbiome in health and diseases.

Share your 'microbiome news' (upcoming talks, new papers, webinars, etc.) and suggestions with us via email at [email protected] or tag us @IMPACTT_Canada. We will spread the news! We wish you all a happy reading!

NEWSROOM

#HavingIMPACTT2021 | June 14-16, 2021

REPLAY FROM THE EXPERTS
The-Human-Milk
The Human Milk: The Ultimate Personalized Medecine
Dr. Meghan Azad, Scientific Director of the IMiC, International Milk Composition Consortium & Natalie Rodriguez, Operations Director of IMiC, explain the dynamic and personalized nature of human milk as a biological system.
Biome-Dr-MC-Arrieta
Fungal Biomes
In this podcast from Microbiome Insights, Dr. Robertson interviewed Dr. Arrieta about the integration of microbial ecology into medical science, challenging the general notion that gut microbiomes are solely fueled by bacterial interactions, understanding the presence and origins of fungi in the developing human microbiome and more!
Research-Innov-Emma-Allan-Vercoe-NuBiyota
Microbes from causation to translation
NuBiyota's startup story
NuBiyota is Dr. Allan Vercoe's company that develops 'biotic drugs' to repair microbiota. Hear from her about the challenges as a new entrepreneur from academia: time, IP management, measuring academic vs industrial success, and more!
UofC-research-highlight
Thermal sensing allows bacteria to control their ability to infect hosts
Dr. Harrison sums up his new discovery about heat sensing in the opportunistic pathogen Pseudomonas aeruginosa. The discovery is currently displayed in the Nature Editors’ Highlights here.

IN THE PRESS
GenomeCanada-COVID
VirusSeq Data a Portal to track the evolving COVID-19 pandemic across Canada.
Genome Canada recently launched VirusSeq Data Portal, a collaborative effort with the participation of Dr. Hsiao & Dr. Brinkman.

ON THE RESEARCH SIDE

NEW PROTOCOLS
Generation, maintenance, and monitoring of gnotobiotic mice. Zucoloto AZ, Yu IL, McCoy KD, McDonald B. STAR Protoc. 2021 May 11. This protocol explains how to generate, maintain, and monitor gnotobiotic mice and three monitoring methods are presented and compared.
Untargeted Stable Isotope Probing of the Gut Microbiota Metabolome Using 13C-Labeled Dietary Fibers. Deng P, et al. J Proteome Res. 2021 May. The authors 'developed an untargeted stable isotope-resolved metabolomics (SIRM) approach for the holistic study of gut microbial metabolites'.
Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches. Lin S, et al. Sci Adv. 2021 May. The authors describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches via the use of yeast membrane.

WITH TRANSLATIONAL POTENTIAL

Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition. Maghraby MK, et al. Sci Rep. 2021 Apr. The authors examine the potential of extracellular vesicles isolated from milk in improving malnutrition-induced atrophy of intestinal mucosa and barrier dysfunction.
Cholecalciferol Supplementation Does Not Prevent the Development of Metabolic Syndrome or Enhance the Beneficial Effects of Omega-3 Fatty Acids in Obese Mice. Valle M, et al. J Nutr. 2021 Apr. The authors 'determined the chronic independent and combined effects of Cholecalciferol and Omega-3 fatty acids on body weight, glucose homeostasis, and markers of inflammation in obese mice'.
Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics. Pirolli NH, et al. Adv Biol (Weinh). 2021 Apr. In this review, the authors summarize 'knowledge of the physiological roles of BEVs as well as state of the art on the development of therapeutic BEVs in the context of the microbiome-gut-brain axis'.

REVIEWS #microbiome #disease #models
The intestinal mycobiome as a determinant of host immune and metabolic health. Gutierrez MW, Arrieta MC. Curr Opin Microbiol. 2021 May. Review the recent studies showing that the gut mycobiome also plays an important role in disease states related to host immunity and energy metabolism.
Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes. Ortega VA, Mercer EM, Giesbrecht GF, Arrieta MC. Front Microbiol. 2021 Apr 7.
The authors explore the evolutionary significance of the stress-axis system for health maintenance and review recent findings that connect early-life microbiome disturbances to alterations in the development of stress response networks
Defined mouse microbiota: An "evolving" tool. Bayer G, Philpott DJ. Cell Host Microbe. 2021 Apr. The authors discuss the study of Yilmaz et al., 'who carried out one of the longest reported in vivo microbiota evolution studies to demonstrate ongoing positive selection of a bacterial consortium within the murine gut'. Key findings for the development of gnotobiotic mouse models.

UPCOMING EVENTS OF INTEREST

Webinars from our network of experts and more!*
Get insights into the multiple facets of human immunology and improve human immunology research with the Canadian Autoimmunity Standardization Core (CAN-ASC) webinar series.
Next ones: Ethics, clinical trials and autoimmunity; Dr. Kimmelman, Professor of Ethics, McGill University | June 25, 10MT - Register here.
*Send us your upcoming microbiome event at [email protected] and we will spread the word!

Upcoming microbiome symposium
Flyer-June14-16-2021
IHMC
Translational-conf-microbiome
Conf-Nature-Reshaping-Microbiome-Nutrition
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Tag us @IMPACTT_Canada
We will spread the News!
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