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IMPACTT Newsletter | November 2020
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This month was a fruitful month in terms of research capacity for faculties with the announcement of new infrastructures and research equipment across Canada. While the University of Calgary announced the re-opening of its BSL3 laboratory, the Canada Fund for Innovation also announced the successful institutions granted with new research equipment to support and develop their research.
Read more about this exciting news, and meet one of the main actors of UCalgary BSL3 reopening initiative, Dr. Paul Kubes, also IMPACTT expert. Finally, we gathered articles presenting cutting-edge technics and methods and also discoveries with translational perspectives.
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Meet our expert Dr. Paul Kubes
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Dr. Paul Kubes is a Professor at the Cumming School of Medicine and the Founding Director of the Snyder Institute for Chronic Diseases at the University of Calgary. As the head of the Infections, Inflammation & Chronic Diseases in the Changing Environment (IICD), Dr. Kubes led the development of the International Microbiome Centre with Dr. McCoy. Dr. Kubes is leading the IMPACTT platform supporting Gnotobiotic Animal Models to Elucidate Causal Mechanisms with Dr. McCoy and Dr. Gros. There he brings his expertise in utilizing real-time in vivo imaging to dissect innate immunity pathways in and understand fundamental mechanisms of immune cell behaviour.
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Owing to their expertise, the Kubes' team made both fundamental and technological breakthroughs which could help improve the treatment of diseases, read more here, here and here. Dr. Kubes is also applying his skills to fighting SARS-CoV-2, see below. Learn more about some of his personal and professional insights in this enticing IMPACTT interview.
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Canadian research capacity is increasing & being strenghtened
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79 projects supported across 52 Canadian institutes and UCalgaryMed BSL3 facility is granted a state-of-the-art microscope, the only one in Canada.
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An informed decision regarding methods #Metagenomics #Bioinformatics
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New methods #Highthroughput #Bioinformatics #Phageomics #Microbialecol.
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ChildHealth, Cohort & Clinical trial
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iPOP - The International Perinatal Outcomes in the Pandemic Study that investigates the impact of pandemic lockdowns on preterm birth and stillbirth, and assess the underlying causative factors.
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Proof of concepts - toward translational applications
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Circadian influence on the microbiome improves heart failure outcomes. Mistry P, et al. J Mol Cell Cardiol. 2020 Sep 19. Using time-restricted feeding, the authors observed that wake time feeding of myocardial infarction (MI) mice improved heart failure outcomes. These benefits were not observed in MI mice fed during their sleep, demonstrating that circadian-mediated gut responses that benefit cardiac repair can be conferred by time-restricted feeding.
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