IMPACTT Newsletter | March 2024

Dear ,

Welcome to our March 2024 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS

Having IMPACTT Microbiome Symposium

The early-bird registration & abstract submission deadline is coming up NEXT WEEK on April 3, 2024 for our Having IMPACTT 4 Symposium (June 3-5, 2024 in Canmore, Canada)! If you are not yet registered, make sure you do so before the prices increase, and don't forget to submit your abstract for presentation. We have an excellent lineup of speakers this year, and lots of presenter awards to hand out. Head to our website to learn more. We can’t wait to see you there!

IMPACTT Mentorship Program

Learn more about our new IMPACTT mentees from our 2024-2025 cohort by checking out our introduction posts on our website and Twitter/X!

Dr. Ann Gregory, University of Calgary
Dr. Elsa Rousseau, Université Laval
Dr. Lauren Davey, University of Victoria
Dr. Maryam Kebbe, University of New Brunswick

Gnotobiotic Workshop

Applications close on March 31, 2024 for our IMPACTT/IMC Gnotobiotic Workshop, happening May 8-10, 2024 at the University of Calgary. We have just one spot left, so if you're interested in attending don't wait to apply!

IMPACTT TEAM & NETWORK NEWS

CBW Microbiome Analysis Workshops

The Canadian Bioinformatics Workshops (bioinformatics.ca) are organizing two microbiome workshops in May 2024 in St. John’s NL, taught by CMI2 Team Grant Lead Dr. Morgan Langille. The Beginner Microbiome Analysis Workshop takes place on May 27-28, 2024 and the Advanced Microbiome Analysis Workshop takes place on May 29-30, 2024. Apply before April 1, 2024 to receive the discounted registration rate of $495 + tax. Registration awards are available! See these and all other CBW workshop announcements here.
Dr. Jayne Danska (IMPACTT Sex & Gender Lead) and colleagues were awarded a new research grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH) in the US. The title of this project grant is The key question (KQ) 1 serum study: Soluble biomarkers for type 1 diabetes risk, development and progression (award 1R01DK138369-01, term 02/2024 – 02/2027). Read more about the project here. Congratulations!

Dr. Carolina Tropini (CMI2 Team Grant Lead) was awarded a Tier II Canada Research Chair in Quantitative Microbiota Biology for Health Applications. Read the announcement here. Congratulations!

NEW PUBLICATIONS

New Publications in the Microbiome World

Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity
Peng et al. [including Platform 2 Lead Dr. Anita Kozyrskyj and CMI2 Team Grant Leads Dr/ Stuart Turvey & Dr. Padmaja Subbarao]. Gut Microbes. 04 Mar 2024.
Highlights: In this study, the researchers investigated whether the gut microbiota plays a role in the increased risk of childhood obesity due to maternal smoking during pregnancy. They followed 1,592 infants from the CHILD study cohort, with environmental and lifestyle data collected prenatally and throughout the first three years of life, and stool samples collected at 3 and 12 months for high-throughput sequencing and magnetic resonance spectroscopy. They found that quitting smoking prior to pregnancy resulted in a similar risk of offspring being overweight as compared to non-smoking controls, but both smoking during pregnancy and quitting smoking during pregnancy carried a higher risk. However, they also found that exclusive breastfeeding until 3 months of age may alleviate these risks. Maternal smoking in pregnancy significantly increased Firmicutes abundance and diversity, potentially contributing to an increased risk of childhood overweight and obesity through excessive butyrate production.
Association between gut microbiota development and allergy in infants born during pandemic-related social distancing restrictions
Korpela et al. [including IMPACTT Co-Applicant Dr. Jens Walter]. Allergy. 29 Feb 2024.
Highlights: In this study, the researchers were interested in whether reduced microbial exposure associated with COVID-19 social distancing measures affected the development of allergies in infants born during this time. They collected fecal samples from infants in the CORAL study cohort at 6 (n=351) and 12 (n=343) months for 16S sequencing, and compared them to previously-published 16S sequencing data collected prior to the pandemic. They found that the CORAL infants had higher relative abundance of bifidobacteria, and lower relative abundance of environmentally transmitted bacteria such as Clostridia, as compared to pre-COVID-19 cohorts. They also found that plant based foods during weaning positively impacted microbiota development. Overall, they did not find an increase in allergen sensitization, food allergy, or atopic dermatitis in the COVID-19 infants, suggesting that vertically transmitted bacteria and appropriate dietary supports may be more important than exposure to environmental microbes alone for protection against allergic diseases in infancy.

New Publications from our IMPACTT Team and Network

Dr. Padmaja Subbarao, Dr. Meghan Azad, & Dr. Stuart Turvey (CMI2 Team Grant Leads)
Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy
Mitina et al. eBioMedicine. 27 Feb 2024.

Dr. Karen Madsen (Platform 3 Lead) & Dr. Eytan Wine (IMPACTT Co-Applicant)
Dichotomous effect of dietary fiber in pediatrics: a narrative review of the health benefits and tolerance of fiber
Basuray et al. European Journal of Clinical Nutrition. 13 Mar 2024.

Dr. Marie-Claire Arrieta (Platform 2 Co-Lead) & Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children
Van de Wouw et al. Microbiome. 21 Mar 2024.

Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead)
Interaction of microbiota, mucosal malignancies, and immunotherapy – mechanistic insights
Mager et al. Mucosal Immunology. 21 Mar 2024.

Dr. Joe Harrison (Platform 3 Co-Lead)
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection
Granton et al. Cell. 21 Mar 2024.

Dr. Celia Greenwood (Platform 5 Lead)
Canadian COVID-19 host genetics cohort replicates known severity associations
Garg et al. PLOS Genetics. 22 Mar 2024.

Dr. Braedon McDonald (Education Co-Lead)
Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Sharma et al. Intensive Care Medicine Experimental. 08 Mar 2024.

Dr. Irina Dinu (IMPACTT Co-Applicant)
The Alberta Infant Motor Scale as an Outcomes Measure of Gross Motor Abilities after Early Complex Cardiac Surgery
Baril et al. Pediatric Cardiology. 21 Mar 2024.

Dr. Janet Hill (IMPACTT Co-Applicant)
Environmental and sociodemographic factors associated with zoonotic pathogen occurrence in Norway rats (Rattus norvegicus) from Windsor, Ontario
Robinson et al. Zoonoses and Public Health. 28 Feb 2024.

Laboratory tools for the direct detection of bacterial respiratory infections and antimicrobial resistance: a scoping review
Adewusi et al. Journal of Veterinary Diagnostic Investigation. 08 Mar 2024.

Dr. Jens Walter (IMPACTT Co-Applicant)
Establishing microbiome causality to tackle malnutrition
Walter. Nature Microbiology. 19 Mar 2024.

Dr. Eytan Wine (IMPACTT Co-Applicant)
Perspectives of patients, parents, and health care providers on facilitators of and barriers to the transition from pediatric to adult care in inflammatory bowel disease: a qualitative descriptive study
Bihari et al. Journal of the Canadian Association of Gastroenterology. 15 Mar 2024.

Letting go of control: A qualitative descriptive study exploring parents’ perspectives on their child’s transition from pediatric to adult care for inflammatory bowel disease
Bihari et al. Journal of Health Psychology. 24 Mar 2024.

Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
The untapped potential of cell culture in disentangling insect-microbial relationships
Macpherson et al. Microbiome Research Reports. 29 Feb 2024.

Dr. Robert Bandsma (CMI2 Team Grant Lead)
Prevalence and correlates of paediatric guideline non-adherence for initial empirical care in six low and middle-income settings: a hospital-based cross-sectional study
Shawon et al. BMJ Open. 08 Mar 2024.

Childhood growth during recovery from acute illness in Africa and South Asia: a secondary analysis of the childhood acute illness and nutrition (CHAIN) prospective cohort
Bourdon et al. eClinicalMedicine. 12 Mar 2024.

Paediatric steatotic liver disease has unique characteristics: A multisociety statement endorsing the new nomenclature
ESPGHAN et al. Journal of Pediatric Gastroenterology and Nutrition. 26 Mar 2024.

Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Association of maternal, obstetric, fetal, and neonatal mortality outcomes with Lady Health Worker coverage from a cross-sectional survey of >10,000 households in Gilgit-Baltistan, Pakistan
Farrar et al. PLOS Global Public Health. 27 Feb 2024.

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
NCD Risk Factor Collaboration. The Lancet. 29 Feb 2024.

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of
GBD 2021 Demographics Collaborators. The Lancet. 11 Mar 2024.

Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study
Montgomery-Csobán et al. The Lancet Digital Health. Apr 2024.

The impact of excluding adverse neonatal outcomes on the creation of gestational weight gain charts among women from low- and middle-income countries with normal and overweight BMI
Carrilho et al. The American Journal of Clinical Nutrition. 22 Mar 2024.

Dr. Anne Griffiths (CMI2 Team Grant Lead)
Outcomes in Adult Inflammatory Bowel Disease Clinical Trials: Assessment of Similarity Among Participants with Adolescent-onset and Adult-onset Disease
Rosh et al. Journal of Crohn’s and Colitis. 26 Feb 2024.

Dr. Steven Kembel (CMI2 Team Grant Lead)
Deep learning- and image processing-based methods for automatic estimation of leaf herbivore damage
Wang et al. Methods in Ecology and Evolution. 27 Feb 2024.

Dr. Caroline Kramer (CMI2 Team Grant Lead)
Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy
Kramer et al. Cardiovascular Diabetology. 18 Mar 2024.

The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RA) on weight loss following bariatric treatment: a systematic review and meta-analysis
Kramer et al. The Journal of Clinical Endocrinology & Metabolism. 15 Mar 2024.

Dr. André Marette (CMI2 Team Grant Lead)
A protectin DX (PDX) analog with in vitro activity against influenza A(H1N1) viruses
Fortin et al. Journal of Medical Virology. 25 Feb 2024.

Dr. Shazeen Suleman (CMI2 Team Grant Lead)
Impact of COVID-19 on the Health of Migrant Children in the United States
Suleman et al. Pediatric Clinics. 09 Mar 2024.

Dr. Stuart Turvey (CMI2 Team Grant Lead)
Finding the balance: The influence of movement behaviours on childhood behaviour problems
Rorem et al. Mental Health and Physical Activity. 12 Mar 2024.

Dr. Maryam Kebbe (IMPACTT Mentee)
Human Milk Components and the Infant Gut Microbiome at 6 Months: Understanding the Interconnected Relationship
Kebbe et al. The Journal of Nutrition. 03 Mar 2024.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world

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