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IMPACTT Newsletter | January 2024
Dear ,
Welcome to our January 2024 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS

IMPACTT/IMC Gnotobiotic Workshop

Applications are open for our IMPACTT/IMC Gnotobiotic Workshop! The workshop will take place over 2.5 days on May 8-10, 2024. This is an excellent opportunity to learn how to conduct gnotobiotic and germ-free research in a state-of-the art facility. Spots are filling up and space is very limited, so don't wait to apply! Visit our website to learn more and apply today.

Having IMPACTT Symposium

Registration & abstract submissions are OPEN for our Having IMPACTT 4 Symposium, which will be held June 3-5, 2024 at the Malcolm Hotel in Canmore, AB! More details are released all the time, so head to our symposium webpage to register now, and don't forget to sign up for updates so you don’t miss any deadlines.

IMPACTT Mentorship Program

Applications have now closed for our 2024-2025 IMPACTT Mentorship Program. Thank you to all who applied! Decisions will be sent out by the end of February. You can learn more about our mentorship program and see past cohorts here.

IMPACTT TEAM & NETWORK NEWS
Dr. Markus Geuking (Education & Mentorship Lead) is welcoming a new MSc student to his lab - welcome, Ailidh McGonigle!

UPCOMING EVENTS

International Congress for Mucosal Immunology

The Society for Mucosal Immunology (SMI) is hosting ICMI 2024 (International Congress of Mucosal Immunology) on July 6-10, 2024 in Copenhagen, Denmark. The deadline to submit abstracts for oral or poster presentations is Jan 31, 2024! Head to their website to register, submit your abstract, and learn more: https://www.socmucimm.org/meetings-events/icmi-2024/

Introduction to R Workshop

The International Microbiome Centre at the University of Calgary is hosting an Introduction to R Workshop on March 21-22, 2024. Registration is $300 and no prerequisites are required! Register here, or email [email protected] for more information.

NEW PUBLICATIONS

New Publications in the Microbiome World

Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course
Schirmer et al. (including CMI2 Team Grant Leads Dr. Anne Griffiths & Dr. David Mack). Cell Host & Microbe. 11 Jan 2024.
Highlights: In this study, the researchers combined paired metagenomics, metabolomics (stool and plasma), and culturomics in order to link disease-associated microbes to microbial metabolites in a pediatric inception cohort focused on ulcerative colitis (UC). They identified host-microbial interactions correlated with disease activity, inflammation, and the clinical course of UC in this cohort. In particular, they found metabolite changes in the stool in severe disease, including increased dipeptides and tauro-conjugated bile acids, as well as decreased amino-acid-conjugated bile acids. They also identified increased plasma polyamines with increasing disease severity. They further discovered that UC-associated Veillonella parvula was able to metabolize immunosuppressive thiopurine drugs, potentially impairing the therapeutic response.

New Publications from our IMPACTT Team and Network

Dr. Thomas Louie & Dr. John Conly (IMPACTT Co-Applicants)
Effectiveness of Bio-K+ for the prevention of Clostridioides difficile infection: Stepped-wedge cluster-randomized controlled trial
Leal et al. Infection Control & Hospital Epidemiology. 11 Dec 2023.
Implementation strategies for hospital-based probiotic administration in a stepped-wedge cluster randomized trial design for preventing hospital-acquired Clostridioides difficile infection
Bresee et al. BMC Health Services Research. 11 Dec 2023.
Dr. Meredith (Merilee) Brockway (IMPACTT Mentee) & Dr. Meghan Azad (CMI2 Team Grant Lead)
Evidence to support targeted investment in breastfeeding education among families of low socioeconomic status
Brockway & Azad. Evidence-Based Nursing. 26 Dec 2023.
Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review
Brockway et al. Advances in Nutrition. 18 Jan 2024.
Dr. Meghan Azad, Dr. Padmaja Subbarao, Dr. Stuart Turvey (CMI2 Team Grant Leads)
Early prediction of pediatric asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort using machine learning
He et al. Pediatric Research. 11 Jan 2024.
Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead)
Melanoma and microbiota: Current understanding and future directions
Routy et al. Cancer Cell. 08 Jan 2024.
Dr. Philippe Gros (Platform 1 Co-Lead)
Human inherited CCR2 deficiency underlies progressive polycystic lung disease
Neehus et al. Cell. 18 Jan 2024.
CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis
Olivier et al. Communications Biology. 10 Jan 2024.
Dr. Paul Kubes (Platform 1 Co-Lead)
A Functional Assessment of Fetal Liver and Monocyte-Derived Macrophages in the Lung Alveolar Environment
Zhang et al. The Journal of Immunology. 22 Jan 2024.
Dr. Ian Lewis (Platform 4 Co-Lead)
Controlled carbonation of Ca(OH)2 surface and its application as an antibacterial particle
Darwish et al. 17 Dec 2023.
Boundary flux analysis: an emerging strategy for investigating metabolic pathway activity in large cohorts
Lewis. Current Opinion in Biotechnology. 07 Dec 2023.
Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3
Hamed et al. Gut Microbes. 11 Dec 2023.
Dr. Celia Greenwood (Platform 5 Lead)
The Mutational Spectrum of Pre- and Post-Neoadjuvant Chemotherapy Triple-Negative Breast Cancers
Aguilar-Mahecha et al. Genes. 23 Dec 2023.
Dr. Diego Silva (Ethics Lead)
Reciprocity, Fairness and the Financial Burden of Undertaking COVID-19 Hotel Quarantine in Australia
Pahlman et al. Public Health Ethics. 20 Dec 2023.
Dr. John Conly (IMPACTT Co-Applicant)
Randomized trial of the safety and efficacy of anti-SARS-CoV-2 mAb in the treatment of patients with nosocomial COVID-19 (CATCO-NOS)
Tremblay et al. Journal of the Association of Medical Microbiology and Infectious Disease. 29 Nov 2023.
Dr. Dongyan Niu (IMPACTT Co-Applicant)
The ileal microbiome and mucosal immune profiles in response to dietary supplementation of ultra-grinded Astragalus membranaceus in weaned goats
Luo et al. Frontiers in Microbiology. 21 Dec 2023.
Dr. Jens Walter (IMPACTT Co-Applicant)
Microbe Profile: The Lactobacillaceae
Walter & O’Toole. Microbiology. 13 Dec 2023.
Plasmid-encoded toxin defence mediates mutualistic microbial interactions
Morais et al. Nature Microbiology. 27 Dec 2023.
Dr. Eytan Wine (IMPACTT Co-Applicant)
Precision nutrition in pediatric IBD: A position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals
Gerasimidis et al. Journal of Pediatric Gastroenterology and Nutrition. 27 Dec 2023.
Dr. Robert Beiko (IMPACTT Co-Applicant)
Mock microbial community meta-analysis using different trimming of amplicon read lengths
Haider et al. Environmental Microbiology. 12 Dec 2023.
Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection
Douchant et al. Communications Biology. 27 Jan 2024.
Dr. Robert Bandsma (CMI2 Team Grant Lead)
A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism
Thind et al. Frontiers in Immunology. 08 Jan 2024.
Accelerometer-based sleep metrics and gut microbiota during adolescence: Association findings from a Brazilian population-based birth cohort
Carpena et al. Sleep Medicine. 13 Jan 2024.
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Humoral and T cell responses to SARS-CoV-2 reveal insights into immunity during the early pandemic period in Pakistan
Masood et al. BMC Infectious Diseases. 01 Dec 2023.
Unravelling the Potential Mortality Benefits of Mass Drug Administration With Azithromycin in Niger
Bhutta. JAMA Network Open. 15 Dec 2023.
An evidence gap map of interventions for noncommunicable diseases and risk factors among children and adolescents
Salam et al. Nature Medicine. 09 Jan 2024.
A Holistic Strategy of Mother and Child Health Care to Improve the Coverage of Routine and Polio Immunization in Pakistan: Results from a Demonstration Project
Habib et al. Vaccines. 16 Jan 2024.
Association between the use of Accredited Social Health Activist (ASHA) services and uptake of institutional deliveries in India
Mishra et al. PLOS Global Public Health. 16 Jan 2024.
Pivoting school health and nutrition programmes during COVID-19 in low- and middle-income countries: A scoping review
Carducci et al. Journal of Global Health. 19 Jan 2024.
Preventing and Controlling Zinc Deficiency Across the Life Course: A Call to Action
Lowe et al. Advances in Nutrition. 26 Jan 2024.
Dr. Gerald Giesbrecht (CMI2 Team Grant Lead)
Early Pregnancy Folic Acid Supplement Use and Folate Status in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study
Tan et al. Proceedings. 01 Dec 2023.
Maternal pre-pregnancy weight status and gestational weight gain in association with child behavior: The mediating role of prenatal systemic inflammation
Vaghef-Mehrabani et al. Clinical Nutrition ESPEN. 20 Dec 2023.
Sex-Specific Associations between Prenatal Exposure to Di(2-ethylhexyl) Phthalate, Epigenetic Age Acceleration, and Susceptibility to Early Childhood Upper Respiratory Infections
Merrill et al. Epigenomes. 26 Jan 2024.
Dr. Anne Griffiths (CMI2 Team Grant Lead)
Outcomes and Endpoints of Postoperative Recurrence in Crohn’s Disease: Systematic Review and Consensus Conference
Hammoudi et al. Journal of Crohn’s and Colitis. 19 Dec 2023.
Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience
Turner et al. Journal of Pediatric Gastroenterology and Nutrition. 10 Dec 2023.
Dr. Tony Lam (CMI2 Team Grant Lead)
Acute activation of GFRAL in the area postrema contributes to glucose regulation independent of weight
Zhang et al. Diabetes. 08 Dec 2023.
Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats
Li et al. Nature Metabolism. 02 Jan 2024.
Dr. Wendy Lou (CMI2 Team Grant Lead)
Increased odds of high body mass index in depression with self-reported antidepressant use
Tassone et al. General Psychiatry. 09 Dec 2023.
Temporal associations of BMI and glucose parameters with depressive symptoms among US adults
Meshkat et al. Psychiatry Research. 10 Jan 2024.
Digital Interventions for Stress Among Frontline Health Care Workers: Results From a Pilot Feasibility Cohort Trial
Espinola et al. JMIR Serious Games. 09 Jan 2024.
Dr. André Marette (CMI2 Team Grant Lead)
Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity
Fernandes et al. Molecular Metabolism. 26 Jan 2024.
Dr. Kelly McNagny (CMI2 Team Grant Lead)
A tumor-restricted glycoform of podocalyxin is a highly selective marker of immunologically cold high-grade serous ovarian carcinoma
Brassard et al. Frontiers in Oncology. 21 Dec 2023
Spatiotemporal signaling underlies progressive vascular rarefaction in myocardial infarction
Tung et al. Nature Communications. 21 Dec 2023.
Dr. Arthur Mortha (CMI2 Team Grant Lead)
Neonatal monocytes suppress adult TH17 cell responses in skin
Tai & Mortha. Nature Reviews Immunology. 04 Dec 2023.
Dr. Aleixo Muise (CMI2 Team Grant Lead)
“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease
Olyha et al. Journal of Clinical Immunology. 17 Jan 2024.
Bioactive interleukin-1 detected in IBD patient intestinal biopsies is a hallmark of ulcers and correlates with transcriptomic assessments, including an ulcer-associated gene module
Losa et al. Gastroenterology. Jan 2024.
Dr. Thomas Murooka (CMI2 Team Grant Lead)
Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence
Zayats et al. Nature Communications. 19 Dec 2023.
Dr. Roger Paredes (CMI2 Team Grant Lead)
In vitro antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota
Rubio-Garcia et al. Frontiers in Cellular and Infection Microbiology. 08 Jan 2024.
Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial
Ubals et al. The Lancet Infectious Diseases. 08 Jan 2024.
Dr. Vanessa Poliquin (CMI2 Team Grant Lead)
Retrospective cohort study of syphilis-related stillbirths in Winnipeg, Manitoba from 2017-2020
Beattie et al. Journal of Obstetrics and Gynaecology Canada. 11 Jan 2024.
Dr. Shazeen Suleman (CMI2 Team Grant Lead)
Comparison of healthcare quality for uninsured and underinsured children through community health centres in Canada and the USA: a scoping review protocol
Suleman et al. BMJ Open. 04 Jan 2024.
Dr. Michael Surette (CMI2 Team Grant Lead)
Human milk oligosaccharides promote intestinal epithelium regeneration independent of the microbiota during necrotizing enterocolitis
Zito et al. Pediatric Surgery International. 12 Jan 2024.
Dr. Carolina Tropini (CMI2 Team Grant Lead)
T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
Pett et al. JoVE Journal. 26 Jan 2024.
Inoviruses
Burckhardt & Tropini. Current Biology. 18 Dec 2023.
Dr. Stuart Turvey (CMI2 Team Grant Lead)
Inborn errors of immunity in adulthood
Wang et al. Allergy, Asthma & Clinical Immunology. 17 Jan 2024.
Naturally occurring splice variants dissect the functional domains of BHC80 and emphasize the need for RNA analysis
Hejla et al. American Journal of Medical Genetics. 24 Jan 2024.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world
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