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IMPACTT Newsletter | April 2024
Dear ,
Welcome to our April 2024 IMPACTT newsletter. Keep reading for news, events, and publications in the microbiome world.

IMPACTT ANNOUNCEMENTS

Having IMPACTT Microbiome Symposium

Our Having IMPACTT 4 Symposium is happening in ONE MONTH on June 3-5, 2024 in Canmore, Canada. There’s still time to register & submit a late-breaking abstract! Head to our website to learn more. We look forward to seeing you there!

Gnotobiotic Workshop

Our SOLD OUT IMPACTT/IMC Gnotobiotic Workshop is taking place next week on May 8-10, 2024 at the University of Calgary. Thank you to everyone who registered, we're excited to host you next week!

IMPACTT TEAM & NETWORK NEWS
Dr. Meghan Azad (CMI2 Team Grant Lead) was the 2024 winner of the Canada Gairdner Momentum Award, initiative of The Gairdner Foundation, recognizing some of the world’s most significant biomedical and global health research and discoveries. Read the announcement here. Congratulations!
Dr. Maryam Kebbe (IMPACTT Mentee) was awarded 1st runner-up at UNB’s 30th Annual Graduate Research Conference 2024 (Social Sciences and Humanities), and also had three students complete their honours projects for the 2023-2024 year. Congratulations!

NEW PUBLICATIONS

New Publications in the Microbiome World
Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial
Zhang et al. [including Platform 3 Lead Dr. Karen Madsen & IMPACTT Co-Applicant Dr. Jens Walter]. Gut Microbes. 29 Apr 2024.
Highlights: In this study, the researchers used data from their recent randomized placebo-control phase 2 clinical trial in adults with obesity and metabolic syndrome. Participants were grouped into HOMA-IR responders and non-responders (HOMA-IR is an assessment for insulin resistance). They found that baseline fecal microbiota composition of the recipients could predict insulin resistance improvements at week 6 of the trial, with the genus Prevotella being identified as an important predictor (lower relative abundance being associated with the responder group). Responders also had increased bacterial richness after FMT and a more consistent engraftment of donor-specific bacteria. Microbial engraftment was also strongly associated with recipient factors at baseline such as initial gut microbial diversity, fiber and nutrient intakes, inflammatory markers, and bile acid derivative levels. The findings of this study provide a basis for the development of precision microbial therapeutics for the treatment of metabolic syndrome.
Assessing phage-host population dynamics by reintroducing virulent viruses to synthetic microbiomes
Wilde et al. [including CMI2 Team Grant Lead Dr. Emma Allen-Vercoe]. Cell Host & Microbe. 22 Apr 2024.
Highlights: One of the challenges of creating synthetic microbiomes is obtaining a representative bacteriophage population during the bacterial isolation process. In this study, the researchers show that dilution-based isolation methods generate synthetic gut microbiomes that are heavily depleted, if not devoid, of virulent viruses. When they re-introduced a virulent dsDNA virome to a 73-strain synthetic gut microbiome in a bioreactor model of the human colon, the researchers found that these virulent viruses targeted susceptible strains without significantly altering the overall community structure or metabolism. They conclude that such viruses, if reintroduced to synthetic gut microbiome models, can have a targeted effect on community assembly, metabolism, and prophage replication.

New Publications from our IMPACTT Team and Network

Dr. Philippe Gros (Platform 1 Co-Lead), Dr. Meghan Azad & Dr. Carolina Tropini (CMI2 Team Grant Leads)
The potential importance of the built-environment microbiome and its impact on human health
Bosch et al. PNAS. 25 Apr 2024.
Dr. Anita Kozyrskyj (Platform 2 Lead), Dr. Fiona Brinkman (Platform 5 Co-Lead), Dr. Padmaja Subbarao, Dr. Meghan Azad, & Dr. Stuart Turvey (CMI2 Team Grant Leads)
The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study
Soliman et al. International Breastfeeding Journal. 08 Apr 2024.
Dr. Anita Kozyrskyj (Platform 2 Lead), Dr. Padmaja Subbarao, Dr. Meghan Azad, & Dr. Stuart Turvey (CMI2 Team Grant Leads)
Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk
Hoskinson et al. Journal of Allergy and Clinical Immunology. 24 Apr 2024.
Dr. Michael Surette, Dr. David Mack, Dr. Anne Griffiths (CMI2 Team Grant Leads) & Dr. Eytan Wine (IMPACTT Co-Applicant)
Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease
Dijk et al. Nutrients. 02 Apr 2024.
Dr. Stuart Turvey, Dr. Padmaja Subbarao (CMI2 Team Grant Leads) & Dr. Qingling Duan (IMPACTT Co-Applicant)
Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study
Lee et al. Environmental Health Perspectives. 04 Apr 2024.
Dr. Stuart Turvey, Dr. Padmaja Subbarao, & Dr. Meghan Azad (CMI2 Team Grant Leads)
Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy
Fehlings et al. Nature Genetics. 29 Mar 2024.
Dr. Kathy McCoy (IMPACTT Director & Platform 1 Lead)
Microbes and vitamin D aid immunotherapy
Franco & McCoy. Science. 25 Apr 2024.
Dr. Laura Sycuro (Platform 4 Lead)
Development and validation of the Cannabis Exposure in Pregnancy Tool (CEPT): a mixed methods study
Chaput et al. BMC Pregnancy and Childbirth. 16 Apr 2024.
Dr. Ian Lewis (Platform 4 Co-Lead)
SCALiR: A Web Application for Automating Absolute Quantification of Mass Spectrometry-Based Metabolomics Data
Ponce et al. Analytical Chemistry. 20 Apr 2024.
Dr. Celia Greenwood (Platform 5 Lead)
Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium
López-Vicente et al. Developmental Psychobiology. 27 Mar 2024.
Dr. Irina Dinu (IMPACTT Co-Applicant)
Differences in gross motor and fine motor outcomes for toddlers after early complex cardiac surgery
Robertson et al. Cardiology in the Young. 12 Apr 2024.
Behavior Concerns in Preschool Cardiac Surgery Survivors
Eliason et al. CJC Pediatric and Congenital Heart Disease. 26 Apr 2024.
Dr. Emma Allen-Vercoe (CMI2 Team Grant Lead)
Apirhabdus apintestini gen. nov., sp. nov., a member of a novel genus of the family Enterobacteriaceae, isolated from the gut of the western honey bee Apis mellifera
Quinn et al. International Journal of Systematic and Evolutionary Microbiology. 23 Apr 2024.
Dr. Robert Bandsma (CMI2 Team Grant Lead)
Paediatric steatotic liver disease has unique characteristics: A multisociety statement endorsing the new nomenclature
Baumann et al. Journal of Pediatric Gastroenterology and Nutrition. 26 Mar 2024.
Dr. Zulfiqar Bhutta (CMI2 Team Grant Lead)
Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
GBD 2021 Causes of Death Collaborators. The Lancet. 03 Apr 2024.
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global burden of Disease Study 2021
GBD 2021 Diseases and Injuries Collaborators. The Lancet. 17 Apr 2024.
Opportunities and challenges for financing women’s, children’s and adolescents’ health in the context of climate change
Anton et al. BMJ Global Health. 27 Apr 2024.
Dr. Anne Griffiths (CMI2 Team Grant Lead)
Operating Properties of Disease Activity Indices in Pediatric Inflammatory Bowel Disease: A Systematic Review
Colman et al. Inflammatory Bowel Diseases. 28 Mar 2024.
Rare and severe adverse events in children with inflammatory bowel disease: analysis of data from the PIBD-SETQuality Safety Registry
Klomberg et al. The Lancet Child & Adolescent Health. 29 Apr 2024.
Dr. Steven Kembel (CMI2 Team Grant Lead)
Winter rye cover crops shelter competent squash phyllosphere bacteria to reduce Pseudomonas syringae pv. lachrymans growth and angular leaf spot symptoms
Maglione et al. Phytopathology. 22 Apr 2024.
Dr. Wendy Lou (CMI2 Team Grant Lead)
Decreased odds of depressive symptoms and suicidal ideation with higher education, depending on sex and employment status
Tassone et al. PLOS One. 03 Apr 2024.
phylaGAN: data augmentation through conditional GANs and autoencoders for improving disease prediction accuracy using microbiome data
Sharma et al. Bioinformatics. 03 Apr 2024.
Botulinum Toxin Injections for Psychiatric Disorders: A Systematic Review of the Clinical Trial Landscape
Demchenko et al. Toxins. 15 Apr 2024.
The association between depressive symptoms and high-sensitivity C-reactive protein: Is body mass index a moderator?
Tassone et al. Brain, Behavior, & Immunity – Health. 18 Apr 2024.
Dr. André Marette (CMI2 Team Grant Lead)
The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids
Lachance et al. Nature Communications. 23 Apr 2024.
Dr. Kelly McNagny (CMI2 Team Grant Lead)
A Retrospective Analysis of Leadership, Awardees, and Member Gender Representation of the Canadian Society for Immunology
Messing et al. The Journal of Immunology. 15 Apr 2024.
Dr. Aleixo Muise (CMI2 Team Grant Lead)
Salmonella exploits membrane reservoirs for invasion of host cells
Zhu et al. Nature Communications. 10 Apr 2024.
Dr. John Parkinson (CMI2 Team Grant Lead)
Intestinal microbiome profiles in broiler chickens raised without antibiotics exhibit altered microbiome dynamics relative to conventionally raised chickens
Kairmi et al. PLOS One. 03 Apr 2024.
Dr. Vanessa Poliquin (CMI2 Team Grant Lead)
Determinants of non-vaccination against seasonal influenza during pregnancy
Guan et al. Canadian Journal of Public Health. 01 Apr 2024.

UPCOMING EVENTS AND REMINDERS

Click here to see curated lists of upcoming events in the microbiome world
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