Platform 1 | Resources
Platform 1 Resources Keep scrolling for posts and pages related to our Platform 1 on Gnotobiotic Animals & Intravital Microscopy. Related Posts Related Pages
Meet Our Platform 1 Co-Lead Dr. Paul Kubes
In this exclusive IMPACTT interview, Dr. Paul Kubes shares personal and professional insights, from the start of his career to what inspires him. Read more for insights on how he became a leader in his field. Where are you from and what brought you to U of C? I trained at Queen’s University (PhD) and […]
New Paper: Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using in vivo live imaging of infected lungs in animal models, Dr. Kubes‘ team and colleagues show that alveolar macrophages patrol the airways and capture inhaled bacteria, but their migration is impaired during viral infection. Their discoveries highlight the importance of finding […]
New Paper: Tacrolimus Impairs Kupffer Cell Capacity to Control Bacteremia: Why Transplant Recipients Are Susceptible to Infection
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using a define mouse model of acute methicillin-resistant Staphylococcus aureus (MRSA) bacteremia along with intravital microscopy, Deppermann C, et al. unravelled why Tacrolimus, a drug used to prevent rejection in solid organ transplant recipients increases the susceptibility of transplant recipient to develop […]
New Paper: Neutrophils Recirculate Through Lymph Nodes to Survey Tissues for Pathogens
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract The adaptive immune function of lymph nodes is dependent on constant recirculation of lymphocytes. In this article, we identify neutrophils present in the lymph node at steady state, exhibiting the same capacity for recirculation. In germ-free mice, neutrophils still recirculate through […]
