Platform 1 | Resources
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New Paper: Innate Responses to Gut Microbiota; Critical Assessment of the Necessary Experimental Controls
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Focusing on the recent findings (since 2017) regarding the commensal bacteria of the mouse intestinal tract, Dr. McCoy and Dr. Ohland discuss the importance and advances of what experimental controls are required to reliably determine how the microbiota influences the […]
Tune in: bacteria may hold a key to some cancer immunotherapies
In these two podcasts, our Director and Platform 1 Lead Dr. Kathy McCoy speaks about her recent study exploring the role of inosine, a bacterial metabolite, in response to cancer immunotherapies. Interviewer Charles Bergquist from Science Friday also raises some important questions such as the recent successes of the microbiome field (Twitter: @scifri). Richard Jacobs […]
New Paper: Microbiome-Derived Inosine Modulates Response to Checkpoint Inhibitor Immunotherapy
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy, as well as our Platform 4 Co-Lead Dr. Ian Lewis and our Education & Mentorship Lead Dr. Markus Geuking, on this recent publication! Using an interdisciplinary approach, the authors identified three bacterial species that significantly enhanced the efficacy of immune checkpoint inhibitors in four […]
New Paper: Mucosal or Systemic Microbiota Exposures Shape the B Cell Repertoire
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! In this intercontinental research effort between Switzerland, Norway, Germany and Canada, Dr. H. Li, colleagues and international collaborators notably Dr. K.D. McCoy, used “localized time-limited exposures of defined doses of single benign microbial taxa in germ-free mice” to “address how […]
New Paper: Neutrophils Recirculate Through Lymph Nodes to Survey Tissues for Pathogens
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract The adaptive immune function of lymph nodes is dependent on constant recirculation of lymphocytes. In this article, we identify neutrophils present in the lymph node at steady state, exhibiting the same capacity for recirculation. In germ-free mice, neutrophils still recirculate through […]
