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Tag: Animal model

New Paper: Fecal Transplant Prevents Gut Dysbiosis and Anxiety-Like Behaviour After Spinal Cord Injury in Rats

Fig 2. Experimental Timeline. Upon arrival, rats were allowed one week to acclimate to their environment before testing. Prior to injury, baseline measures were obtained in the cylinder test, open field, light-dark box and sucrose preference tests. With the exception of the healthy group, all rats were gavaged with a fecal slurry (FMT: fecal microbiota transplant) or control solution at the time of injury and for 2 days following injury or sham surgery. Stool samples were collected for 16s rRNA sequencing prior to, 3 days and 4 weeks following surgeries. After surgeries, rats were tested weekly on a battery of behavioural tests followed by perfusions (5 weeks following surgeries) and tissue analysis.

A model of anxiety following a cervical contusion spinal cord injury in rats demonstrates fecal transplant prevents gut dysbiosis and anxiety-like behaviour

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