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General Microbiome
Pregnancy & Early Life
Health & Disease
Antimicrobial Resistance
Microbiome & Immunity

General Microbiome

New Paper: Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

Congratulations to our Platform 2 Co-Lead Dr. Marie-Claire Arrieta on this recent publication! Abstract Whether the human fetus and the prenatal intrauterine environment (amniotic fluid

New Paper: Immunometabolism and microbial metabolites at the gut barrier: lessons for therapeutic intervention in Inflammatory Bowel Disease

Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Abstract The concept of immunometabolism has emerged recently whereby repolarizing of inflammatory

New Paper: Long-Distance Relationships – Regulation of Systemic Host Defense Against Infections by the Gut Microbiota

Congratulations to our Education & Mentorship Leads Dr. Markus Geuking and Dr. Braedon McDonald on this recent publication! Abstract Despite compartmentalization within the lumen of

New Paper: From Germ-Free to Wild: Modulating Microbiome Complexity to Understand Mucosal Immunology

Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract The gut microbiota inﬂuences host responses at practically

Green spaces may be beneficial for early life microbiota, be outdoorsy!

Analyzing and mapping the microbiota of 355 4 month-old infants to their area of living, Dr. Kozyrskyj and her colleagues revealed that living close by

New Paper: Intestinal Fungi are Causally Implicated in Microbiome Assembly and Immune Development in Mice

Intestinal fungi are causally implicated in microbiome assembly and immune development in mice.

Fig 1. The perinatal period represents a time in development when exogenous factors that affect the microbiome such as antibiotics, diet, hygiene, pathogens, mode of birth, and pollutants can alter immune and physiological programming. The effects of early-life programming may lead to increased disease susceptibility later in life. Created with BioRender.com from The impact of maternal and early life malnutrition on health: a diet-microbe perspective.

The impact of maternal and early life malnutrition on health: a diet-microbe perspective.

Provide an overview of factors implicated in the progression of malnutrition during early life, discuss the microbiota that may contribute to health risk.

Fig 3. Drivers of gut bacterial beta-diversity and indicator taxa associated with maternal consumption of ASB differ between clusters. (A) Univariate models showing significance and explained variance of 10 variables on bacterial community structure across all data and each cluster subset. Horizontal bars show the amount of variance (R2) explained by each covariate in the model as determined by envfit. Asterisk denotes the significant covariates in each data subset (P

New Paper: Consumption of Artificially Sweetened Beverages During Pregnancy Impacts Infant Gut Microbiota and Body Mass Index

Study finds that artificially sweetened beverages consumption during pregnancy impacts mother’s microbiota and might lead to higher infant BMI.

New Paper: Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract

Congratulations to our Education & Mentorship Co-Lead Dr. Braedon McDonald on this recent publication! Abstract Extra-intestinal pathogenic Escherichia coli (ExPEC) can cause a variety of infections outside

New Paper: Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk

Congratulations to our Platform 5 Lead Dr. Celia Greenwood on this recent publication! Abstract Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores

New Paper: Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives

Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Abstract Background & AimsThe cause of Crohn’s disease (CD) is unknown, but

New Paper: Immunometabolism and microbial metabolites at the gut barrier: lessons for therapeutic intervention in Inflammatory Bowel Disease

Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Abstract The concept of immunometabolism has emerged recently whereby repolarizing of inflammatory

Fig5.b.Decreasing-antibiotic-use-the-gut-microbiota-and-asthma-incidence-in-children-evidence-from-population-based-and-prospective-cohort-studies

New Paper: Decreasing Antibiotic Use, The Gut Microbiota, and Asthma Incidence in Children: Evidence From Population-Based and Prospective Cohort Studies

The authors investigated if the decreases in asthma incidence are linked to reduced antibiotic prescribing and mediated by changes in the gut microbiota.

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