New Paper: Tacrolimus Impairs Kupffer Cell Capacity to Control Bacteremia: Why Transplant Recipients Are Susceptible to Infection

Snapshot of Movie 1 showing a decrease in the number of bacteria adhering to Kupffer cells of mice treated with Tacrolimus during the first 30 min.

Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using a define mouse model of acute methicillin-resistant Staphylococcus aureus (MRSA) bacteremia along with intravital microscopy, Deppermann C, et al. unravelled why Tacrolimus, a drug used to prevent rejection in solid organ transplant recipients increases the susceptibility of transplant recipient to develop […]

New Paper: Mucosal or Systemic Microbiota Exposures Shape the B Cell Repertoire

Gut microbes shape our antibodies before we are infected by pathogens - Gut-Flora-Illustration

Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! In this intercontinental research effort between Switzerland, Norway, Germany and Canada, Dr. H. Li, colleagues and international collaborators notably Dr. K.D. McCoy, used “localized time-limited exposures of defined doses of single benign microbial taxa in germ-free mice” to “address how […]